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Št. zadetkov: 2
Design, synthesis and evaluation of DNA gyrase B inhibitors based on the benzothiazole scaffold
Marina Gjorgjieva, Danijel Kikelj, Lucija Peterlin-Mašič
Doktorska disertacija
Oznake: protibakterijske učinkovine;bakterijska rezistenca;DNA-giraza;inhibitorji;načrtovanje;sinteza;vrednotenje;disertacije;
Antibacterial resistance has become a huge problem lately. The big euphoria from the middle of the previous century with the discovery of the antibiotics did not last for long. Soon after the discovery of the first antibiotics, researchers realized that the fight with the microbes would not be so ea ...
Leto: 2016 Vir: Fakulteta za farmacijo (UL FFA)
Discovery of benzothiazole scaffold-based DNA gyrase B inhibitors
Marina Gjorgjieva, Tihomir Tomašić, Michaela Barančokova, Sotirios Katsamakas, Janez Ilaš, Päivi Tammela, Lucija Peterlin-Mašič, Danijel Kikelj
Izvirni znanstveni članek
Oznake: bioanorganska kemija;koordinacijske spojine;organorutenijevi kompleksi;diketonati;citotoksičnost;protirakava zdravila;organoruthenium complexes;diketonates;anticancer drugs;ROS;cytotoxicity;cell cycle arrest;
Bacterial DNA gyrase and topoisomerase IV control the topological state of DNA during replication and are validated targets for antibacterial drug discovery. Starting from our recently reported 4,5,6,7-tetrahydrobenzo[1,2-d]thiazole-based DNA gyrase B inhibitors, we replaced their central core with ...
Leto: 2016 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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