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Št. zadetkov: 2
Detection of potential actinobacterial inhibitors of bacterium Clostridium difficile Mur ligases
Monika Pušić, Blaž Stres, Martin Sievers, Maja Rupnik
Magistrsko delo
Oznake: molecular biology;cloning;Clostridium difficile;Mur ligases;protein expression;purification;inhibitory assay;
Clostridium difficile is one of the major public health treats nowadays as C. difficile infections (CDI) represent the majority of health-care associated infections. This is due to the standard treatment with broad-spectrum antibiotics, vancomycin and metronidazole. Treatment results in disrupted mi ...
Leto: 2019 Vir: Biotehniška fakulteta (UL BF)
Antimicrobial potential of actinobacterial inhibitors of MurA and MurB ligases in bacterium Clostridium difficile
Elmedine Rustemi, Blaž Stres, Martin Sievers, Maja Rupnik
Magistrsko delo
Oznake: molecular biology;cloning;Clostridium difficile;Mur ligases;actinobacterial inhibitors;protein expression;insect cells;purification;inhibitory assay;
Enzymes MurA, MurB and MurC catalyze the initial cytoplasmic steps of peptidoglycan biosynthesis. Mur ligases are highly conserved among various bacterial species with a high potential to become targets for new classes of antimicrobial agents. Main aim of this study was production of recombinant Mur ...
Leto: 2019 Vir: Biotehniška fakulteta (UL BF)
Št. zadetkov: 2
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