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Št. zadetkov: 2
Diferential roles of eNOS in late efects ofVEGF‑A on hyperpermeability in diferent types of endothelial cells
Esmeralda K. Bosma, Shahan Darwesh, Yasmin I. Habani, Maxime Cammeraat, Paola Serrano Martinez, Mathilda E. van Breest Smallenburg, JiaY. Zheng, Ilse M.C. Vogels, Cornelis J. F. van Noorden, Reinier O. Schlingemann, Ingeborg Klaassen
Izvirni znanstveni članek
Oznake: endocytosis;RNAi;hyperpermeability;
Vascular endothelial growth factor (VEGF)-A induces endothelial hyperpermeability, but the molecular pathways remain incompletely understood. Endothelial nitric oxide synthase (eNOS) regulates acute efects of VEGF-A on permeability of endothelial cells (ECs), but it remains unknown whether and how e ...
Leto: 2023 Vir: Nacionalni inštitut za biologijo (NIB)
New insights in ATP synthesis as therapeutic target in cancer and angiogenic ocular diseases
Cornelis J. F. van Noorden, Bahar Yetkin-Arik, Paola Serrano Martinez, Noëlle Bakker, Mathilda E. van Breest Smallenburg, Reinier O. Schlingemann, Ingeborg Klaassen, Bernarda Majc, Anamarija Habič, Urban Bogataj, Katrin S. Galun, Miloš Vittori, Mateja Erdani-Kreft, Metka Novak, Barbara Breznik, Vashendriya V. V. Hira
Pregledni znanstveni članek
Oznake: aerobic glycolysis;anaerobic glycolysis;angiogenesis;ATP synthesis;cancer cells;cancer stem cells;endothelial cells;energy metabolism;eye diseases;oxidative phosphorylation;pericytes;retina;Warburg effect;
Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) also produce lactate and ATP by aerobic glycolysis. In fact, all proliferating cells, both non-cancer and ...
Leto: 2024 Vir: Nacionalni inštitut za biologijo (NIB)
Št. zadetkov: 2
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