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Št. zadetkov: 6
High FREM2 gene and protein expression are associated with favorable prognosis of IDH-WT glioblastomas
Ivana Jovchevska, Alja Zottel, Neja Zupanec, Jernej Mlakar, Maxim Sorokin, Daniil Nikitin, Anton A. Buzdin, Radovan Komel
Izvirni znanstveni članek
Oznake: glioblastoma;malignancy;FREM2;SPRY1;TCGA;
World Health Organization grade IV diffuse gliomas, known as glioblastomas, are the most common malignant brain tumors, and they show poor prognosis. Multimodal treatment of surgery followed by radiation and chemotherapy is not sufficient to increase patient survival, which is 12 to 18 months after ...
Leto: 2019 Vir: Medicinska fakulteta (UL MF)
Algorithmically deduced FREM2 molecular pathway is a potent grade and survival biomarker of human gliomas
Marianna Zolotovskaia, Victor Tkachev, Maxim Sorokin, Andrew Garazha, Ella Kim, Sven Rainer Kantelhardt, Alja Zottel, Neja Zupanec, Ivana Jovchevska
Izvirni znanstveni članek
Oznake: gliom;glioblastom;napoved preživetja;glioma;glioblastoma;survival prognosis;
Gliomas are the most common malignant brain tumors with high mortality rates. Recently we showed that the FREM2 gene has a role in glioblastoma progression. Here we reconstructed the FREM2 molecular pathway using the human interactome model. We assessed the biomarker capacity of FREM2 expression and ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Molecular heterogeneity in breast carcinoma cells with increased invasive capacities
Giulia Negro, Bertram Aschenbrenner, Simona Kranjc, Maja Čemažar, Andrej Cör, Gorana Gašljević, Maxim Sorokin, Anton A. Buzdin, Maurizio Callari, Irma Kvitsaridze
Izvirni znanstveni članek
Oznake: breast cancer;cancer stem cells;invasiveness;migration;metastasis;
Metastatic progression of breast cancer is still a challenge in clinical oncology. Therefore, an elucidation how carcinoma cells belonging to different breast cancer subtypes realize their metastatic capacities is needed. The aim of this study was to elucidate a similarity of activated molecular pat ...
Leto: 2020 Vir: Onkološki inštitut Ljubljana (OI)
Simvastatin is effective in killing the radioresistant breast carcinoma cells
Bertram Aschenbrenner, Giulia Negro, Dragana Savic, Maxim Sorokin, Anton A. Buzdin, Ute Maria Ganswindt, Maja Čemažar, Gregor Serša, Sergej Skvortsov, Ira Skvortsova
Izvirni znanstveni članek
Oznake: radiotherapy;breast cancer;radioresistant cells;
Background. Statins, small molecular 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, are widely used to lower cholesterol levels in lipid-metabolism disorders. Recent preclinical and clinical studies have shown that statins exert beneficial effects in the management of breast cancer by i ...
Leto: 2021 Vir: Onkološki inštitut Ljubljana (OI)
Large-scale transcriptomics-driven approach revealed overexpression of CRNDE as a poor survival prognosis biomarker in glioblastoma
Maxim Sorokin, Mikhail Raevskiy, Alja Zottel, Neja Zupanec, Marija Skoblar Vidmar, Alenka Matjašič, Andrej Zupan, Jernej Mlakar, Maria Suntsova, Denis V. Kuzmin, Anton A. Buzdin, Ivana Jovchevska
Izvirni znanstveni članek
Oznake: glioblastom;nekodirajoča RNA;dolgoročno preživetje;glioblastoma;noncoding RNA;long-term survival;
Glioblastoma is the most common and malignant brain malignancy worldwide, with a 10-year survival of only 0.7%. Aggressive multimodal treatment is not enough to increase life expectancy and provide good quality of life for glioblastoma patients. In addition, despite decades of research, there are no ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Analysis of miR-9-5p, miR-124-3p, miR-21-5p, miR-138-5p, and miR-1-3p in glioblastoma cell lines and extracellular vesicles
Alja Zottel, Neja Zupanec, Ana Kump, Lucija Raspor Dall'Olio, Pia Pužar Dominkuš, Rok Romih, Samo Hudoklin, Jernej Mlakar, Daniil Nikitin, Maxim Sorokin, Anton A. Buzdin, Ivana Jovchevska, Radovan Komel
Izvirni znanstveni članek
Oznake: glioblastom;biomarkerji;eksosomi;glioblastoma;biomarkers;exosomes;
Glioblastoma (GBM), the most common primary brain tumor, is a complex and extremely aggressive disease. Despite recent advances in molecular biology, there is a lack of biomarkers, which would improve GBM's diagnosis, prognosis, and therapy. Here, we analyzed by qPCR the expression levels of a set o ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 6
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