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Št. zadetkov: 13
Antiangiogeni in radiosenzibilizirajoči učinek elektrogenske terapije proti endoglinu na eksperimentalnih tumorskih modelih
Monika Štimac, Gregor Serša, Tomaž Jarm
Doktorska disertacija
Oznake: elektrogenska terapija;endoglin;elektroporacija;antiangiogeni učinek;radiosenzibilizirajoči učinek;plazmidi;miši;
Antiangiogeni in radiosenzibilizirajoči učinek elektrogenske terapije proti endoglinu na eksperimentalnih tumorskih modelih
Leto: 2017 Vir: Repozitorij Univerze v Ljubljani (RUL)
Optimizacija in validacija metode za barvanje krvnih žil v mišjih tumorskih modelih
Monika Štimac, Maja Čemažar, Rok Kostanjšek
Magistrsko delo
Oznake: onkologija;karcinogeza;antiangiogena terapija;genska terapija;magistrske naloge;endoglin;
Optimizacija in validacija metode za barvanje krvnih žil v mišjih tumorskih modelih
Leto: 2012 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Kombinacija obsevanja in žilno ciljane genske terapije za CD105 ter CD146
Monika Štimac, Maja Čemažar, Gregor Serša
Objavljeni znanstveni prispevek na konferenci (vabljeno predavanje)
Oznake: obsevanje;genska terapija;klinične študije;
Kombinacija obsevanja in žilno ciljane genske terapije za CD105 ter CD146
Leto: 2022 Vir: Onkološki inštitut Ljubljana (OI)
Electrotransfer of plasmid DNA radiosensitizes B16F10 tumors through activation of immune response
Monika Štimac, Urška Kamenšek, Maja Čemažar, Richard Heller, Gregor Serša
Izvirni znanstveni članek
Oznake: gene therapy;electrotransfer;plasmid;irradiation;immune response;melanoma;
Tumor irradiation combined with adjuvant treatments, either vascular targeted or immunomodulatory, is under intense investigation. Gene electrotransfer of therapeutic genes is one of these approaches. The aim of this study was to determine, whether gene electrotransfer of plasmid encoding shRNA for ...
Leto: 2017 Vir: Onkološki inštitut Ljubljana (OI)
Evaluation of a novel plasmid for simultaneous gene electrotransfer-mediated silencing of CD105 and CD146 in combination with irradiation
Monika Štimac, Urška Kamenšek, Katarina Žnidar, Vesna Todorović, Gregor Serša, Maja Čemažar
Izvirni znanstveni članek
Oznake: CD105;CD146;plazmidi;elektroprenos genov;plasmid;gene electrotransfer;
Targeting tumor vasculature through specific endothelial cell markers represents a promising approach for cancer treatment. Here our aim was to construct an antibiotic resistance gene-free plasmid encoding shRNAs to simultaneously target two endothelial cell markers, CD105 and CD146, and to test its ...
Leto: 2021 Vir: Onkološki inštitut Ljubljana (OI)
Radiosenzibilizacija tumorjev z elektroprenosom plazmida za dve antiangiogeni tarči
Monika Štimac, Katarina Žnidar, Gregor Serša, Tilen Komel, Maja Čemažar, Urška Kamenšek
Objavljeni povzetek znanstvenega prispevka na konferenci
Oznake: miši;elektroprenos genov;gensko zdravljenje;
Leto: 2023 Vir: Onkološki inštitut Ljubljana (OI)
Tumor radiosensitization by gene electrotransfer-mediated double targeting of tumor vasculature
Monika Štimac, Katarina Žnidar, Gregor Serša, Tilen Komel, Maja Čemažar, Urška Kamenšek
Izvirni znanstveni članek
Oznake: genski elektroprenos;adenokarcinom;radiosensitizacija;gene electrotransfer;adenocarcinom;radiosensitization;
Abstract: Targeting the tumor vasculature through specific endothelial cell markers involved in different signaling pathways represents a promising tool for tumor radiosensitization. Two prominent targets are endoglin (CD105), a transforming growth factor β co-receptor, and the melanoma cell adhesio ...
Leto: 2023 Vir: Zdravstvena fakulteta (UL ZF)
APS8 delays tumor growth in mice by inducing apoptosis of lung adenocarcinoma cells expressing high number of [alfa]7 nicotinic receptors
Sabina Berne, Maja Čemažar, Robert Frangež, Polona Juntes, Simona Kranjc, Marjana Grandič, Monika Štimac, Tom Turk
Izvirni znanstveni članek
Oznake: lung cancer;antitumor activity;A549;HT29;CHRNA7;alkylpiridinium;SCID mice;toxicity;apoptosis;lung neoplasms;therapy;nicotinic receptors;
The alkylpyridinium polymer APS8, a potent antagonist of α7 nicotinic acetylcholine receptors (nAChRs), selectively induces apoptosis in non-small cell lung cancer cells but not in normal lung fibroblasts. To explore the potential therapeutic value of APS8 for at least certain types of lung cancer, ...
Leto: 2018 Vir: Biotehniška fakulteta (UL BF)
Adjuvant TNF-a therapy to electrochemotherapy with intravenous cisplatin in murine sarcoma exerts synergistic antitumor effectiveness
Maja Čemažar, Vesna Todorović, Janez Ščančar, Urša Lampreht Tratar, Monika Štimac, Urška Kamenšek, Simona Kranjc, Andrej Cör, Gregor Serša
Izvirni znanstveni članek
Oznake: electrochemotherapy;TNF;adjuvant immunotherapy;cisplatin;
Background. Electrochemotherapy is a tumour ablation modality, based on electroporation of the cell membrane, allowing non-permeant anticancer drugs to enter the cell, thus augmenting their cytotoxicity by orders of magnitude. In preclinical studies, bleomycin and cisplatin proved to be the most sui ...
Leto: 2015 Vir: Onkološki inštitut Ljubljana (OI)
Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivity
Vesna Todorović, Ajda Prevc, Martina Nikšić Žakelj, Monika Štimac, Simon Buček, Blaž Grošelj, Primož Strojan, Maja Čemažar, Gregor Serša
Izvirni znanstveni članek
Oznake: DNA damage;isogenic cell lines;low dose irradiation;pulsed low dose-rate irradiation;radiosensitivity;
. Management of locoregionally recurrent head and neck squamous cell carcinomas (HNSCC) is challenging due to potential radioresistance. Pulsed low-dose rate (PLDR) irradiation exploits phenomena of increased radiosensitivity, low-dose hyperradiosensitivity (LDHRS), and inverse dose-rate effect. The ...
Leto: 2020 Vir: Onkološki inštitut Ljubljana (OI)
Št. zadetkov: 13
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