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Št. zadetkov: 2
Cathepsin L-mediated EGFR cleavage affects intracellular signalling pathways in cancer
Marija Grozdanić, Barbara Sobotič, Monika Biasizzo, Tilen Sever, Robert Vidmar, Matej Vizovišek, Boris Turk, Marko Fonović
Izvirni znanstveni članek
Oznake: cancer;cysteine cathepsin;cathepsin L;EGFR;extracellular cleavage;resistance to TKIs;
Proteolytic activity in the tumour microenvironment is an important factor in cancer development since it can also affect intracellular signalling pathways via positive feedback loops that result in either increased tumour growth or resistance to anticancer mechanisms. In this study, we demonstrated ...
Leto: 2022 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Cystatin C deficiency increases LPS-induced sepsis and NLRP3 inflammasome activation in mice
Monika Biasizzo, Mojca Trstenjak-Prebanda, Klemen Dolinar, Sergej Pirkmajer, Janja Završnik, Boris Turk, Nataša Kopitar-Jerala
Izvirni znanstveni članek
Oznake: cistatin C;lipopolisaharid;vnetni virus NLRP3;cystatin C;lipopolysaccharide;NLRP3 inflammasome;
Cystatin C is a potent cysteine protease inhibitor that plays an important role in various biological processes including cancer, cardiovascular diseases and neurodegenerative diseases. However, the role of CstC in inflammation is still unclear. In this study we demonstrated that cystatin C-deficien ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 2
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