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ǂA ǂphase Ib clinical trial of metformin and chloroquine in patients with IDH1-mutated solid tumors
Mohammed Khurshed, Remco J. Molenaar, Myra E van Linde, Ron Mathôt, Eduard A. Struys, Tom van Wezel, Cornelis J. F. van Noorden, Heinz-Josef Klümpen, Judith V. M. G. Bovée, Johanna W Wilmink
Izvirni znanstveni članek
Oznake: metformin;chloroquine;cancer;isocitrate dehydrogenase;pharmacokinetics;glioblastoma;intrahepatic cholangiocarcinoma;chondrosarcoma;
Background: Mutations in isocitrate dehydrogenase 1 (IDH1) occur in 60% of chondrosarcoma, 80% of WHO grade II-IV glioma and 20% of intrahepatic cholangiocarcinoma. These solid IDH1-mutated tumors produce the oncometabolite D-2-hydroxyglutarate (D-2HG) and are more vulnerable to disruption of their ...
Leto: 2021 Vir: Nacionalni inštitut za biologijo (NIB)
Št. zadetkov: 1
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