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Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacy
Maja Kokot, Matjaž Weiss, Irena Zdovc, L. Šenerović, Natasa Radakovic, Marko Anderluh, Nikola Minovski, Martina Hrast
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Oznake: DNA giraza;topoizomeraza IV;antibakterijska zdravila;inhibicija;učinkovitost in vivo;NBTIs;DNA gyrase;Topoisomerase IV;antibacterials;MRSA;hERG inhibition;in vivo efficacy;
Novel bacterial topoisomerase inhibitors (NBTIs) are new promising antimicrobials for the treatment of multidrug-resistant bacterial infections. In recent years, many new NBTIs have been discovered, however most of them struggle with the same issue - the balance between antibacterial activity and hE ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
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