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Št. zadetkov: 2
Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacy
Maja Kokot, Matjaž Weiss, Irena Zdovc, L. Šenerović, Natasa Radakovic, Marko Anderluh, Nikola Minovski, Martina Hrast
Izvirni znanstveni članek
Oznake: DNA giraza;topoizomeraza IV;antibakterijska zdravila;inhibicija;učinkovitost in vivo;NBTIs;DNA gyrase;Topoisomerase IV;antibacterials;MRSA;hERG inhibition;in vivo efficacy;
Novel bacterial topoisomerase inhibitors (NBTIs) are new promising antimicrobials for the treatment of multidrug-resistant bacterial infections. In recent years, many new NBTIs have been discovered, however most of them struggle with the same issue - the balance between antibacterial activity and hE ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Designing the DNA-intercalating moiety to improve the safety and efficacy of novel bacterial topoisomerase inhibitors
Maša Zorman, Živa Zajec, Irena Zdovc, L. Šenerović, Natasa Radakovic, Marija Atanasković, Marko Anderluh, Nikola Minovski, Martina Hrast
Izvirni znanstveni članek
Oznake: bacteria;peptides and proteins;extraction;inhibition;nuclear magnetic resonance spectroscopy;
Novel bacterial topoisomerase inhibitors (NBTIs) target bacterial topoisomerases through binding modes distinct from fluoroquinolones but are often limited by hERG channel inhibition. Our previous findings indicated that the introduction of a non-aminopiperidine linker and a halogenated phenyl enzym ...
Leto: 2026 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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