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Investigating the influence of processing conditions on dissolution and physical stability of solid dispersions with fenofibrate and mesoporous silica
Ana Baumgartner, Nina Dobaj, Odon Planinšek
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Oznake: mezoporozni silicijev dioksid;amorfna trdna disperzija;metoda izhlapevanja topila;raztapljanje fenofibrata;fizična stabilnost;mesoporous silica;amorphous solid dispersion;solvent evaporation method;fenofibrate dissolution;physical stability;
The study aimed to enhance the solubility of the poorly water-soluble drug, fenofibrate, by loading it onto mesoporous silica, forming amorphous solid dispersions. Solid dispersions with 30% fenofibrate were prepared using the solvent evaporation method with three solvents (ethyl acetate, acetone, a ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
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