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Št. zadetkov: 2
Wide-antimicrobial spectrum of picolinium salts
Sarka Salajkova, Marketa Benkova, Jan Marek, Radek Sleha, Lukas Prchal, David Malinak, Rafael Dolezal, Kristina Sepčić, Nina Gunde-Cimerman, Kamil Kuca, Ondrej Soukup
Izvirni znanstveni članek
Oznake: pikolinijeve soli;kvartarne amonijeve spojine;surfaktant;kritična micelarna koncentracija;protimikrobna aktivnost;citotoksičnost;picolinium salts;quaternary ammonium compounds;surfactant;critical micellar concentration;antimicrobial activity;cytotoxicity;
Nosocomial infections, which greatly increase morbidity among hospitalized patients, together with growing antibiotic resistance still encourage many researchers to search for novel antimicrobial compounds. Picolinium salts with different lengths of alkyl chains (C$_{12}$, C$_{14}$, C$_{16}$) were p ...
Leto: 2020 Vir: Biotehniška fakulteta (UL BF)
Synthesis and biological evaluation of benzochromenopyrimidinones as cholinesterase inhibitors and potent antioxidant, non-hepatotoxic agents for Alzheimer's disease
Youssef Dgachi, Oscar M. Bautista-Aguilera, Mohamed Benchekroun, Hélène Martin, Alexandre Bonet, Damijan Knez, Justyna Godyń, Barbara Malawska, Stanislav Gobec, Mourad Chioua, Jana Janockova, Ondrej Soukup, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Izvirni znanstveni članek
Oznake: Alzheimer's disease;quinazolinones;multicomponent reactions;multitarget-directed ligands;antioxidants;cholinesterase inhibitors;hepatotoxicity;
We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixed-type inhibition of human acetylcholinesterase (I ...
Leto: 2016 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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