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Use of HuH6 and other human-derived hepatoma lines for the detection of genotoxins
Monika Waldherr, Miroslav Mišík, Franziska Ferk, Jana Tomc, Bojana Žegura, Metka Filipič, Wolfgang Mikulits, Sören Mai, Oskar Haas, Wolfgang W. Huber, Elisabeth Haslinger, Siegfried Knasmüller
Izvirni znanstveni članek
Oznake: hepatic cell lines;p53;comet assay;genotoxicity;
Cell lines which are currently used in genotoxicity tests lack enzymes which activate/detoxify mutagens. Therefore, rodent-derived liver preparations are used which reflect their metabolism in humans only partly; as a consequence misleading results are often obtained. Previous findings suggest that ...
Leto: 2018 Vir: Nacionalni inštitut za biologijo (NIB)
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