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Št. zadetkov: 2
Mitochondria can substitute for parvalbumin to lowercytosolic calcium levels in the murine fast skeletal muscle
Lorenzo Marcucci, Leonardo Nogara, Marta Canato, Elena Germinario, Anna Raffaello, Michela Carraro, Paolo Bernardi, Laura Pietrangelo, Simona Boncompagni, Feliciano Protasi, Nazareno Paolocci, Carlo Reggiani
Izvirni znanstveni članek
Oznake: calcium;mitochondria;mouse skeletal muscle fibers;parvalbumin;reaction-diffusion model;
Aim: Parvalbumin (PV) is a primary calcium buffer in mouse fast skeletal musclefibers. Previous work showed that PV ablation has a limited impact on cytosolicCa2+ ([Ca2+]cyto) transients and contractile response, while it enhances mitochon-drial density and mitochondrial matrix-free calcium concentr ...
Leto: 2024 Vir: Univerza na Primorskem (UP)
New insights in ATP synthesis as therapeutic target in cancer and angiogenic ocular diseases
Cornelis J. F. van Noorden, Bahar Yetkin-Arik, Paola Serrano Martinez, Noëlle Bakker, Mathilda E. van Breest Smallenburg, Reinier O. Schlingemann, Ingeborg Klaassen, Bernarda Majc, Anamarija Habič, Urban Bogataj, Katrin S. Galun, Miloš Vittori, Mateja Erdani-Kreft, Metka Novak, Barbara Breznik, Vashendriya V. V. Hira
Pregledni znanstveni članek
Oznake: aerobic glycolysis;anaerobic glycolysis;angiogenesis;ATP synthesis;cancer cells;cancer stem cells;endothelial cells;energy metabolism;eye diseases;oxidative phosphorylation;pericytes;retina;Warburg effect;
Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) also produce lactate and ATP by aerobic glycolysis. In fact, all proliferating cells, both non-cancer and ...
Leto: 2024 Vir: Nacionalni inštitut za biologijo (NIB)
Št. zadetkov: 2
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