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ǂA ǂcrucial active site network of titratable residues guides catalysis and NAD[sup]+ binding in human succinic semialdehyde dehydrogenase
Samuele Cesaro, Marco Orlando, Ilaria Bettin, Carmen Longo, Giulia Spagnoli, Patrizia Polverino de Laureto, Gianluca Molla, Mariarita Bertoldi
Izvirni znanstveni članek
Oznake: bioinformatic analysis;evolutionary analysis;enzymatic mechanism;kinetics;succinic semialdehyde dehydrogenase;succinic semialdehyde dehydrogenase deficiency;
Human succinic semialdehyde dehydrogenase is a mitochondrial enzyme fundamental in the neurotransmitter γ‐aminobutyric acid catabolism. It catalyzes the NAD+‐dependent oxidative degradation of its derivative, succinic semialdehyde, to succinic acid. Mutations in its gene lead to an inherited neurome ...
Leto: 2025 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
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