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Št. zadetkov: 3
ǂA ǂnovel dual-cytokine-antibody fusion protein for the treatment of CD38-positive malignancies
Roberto De Luca, Paul Kachel, Klara Kropivšek, Berend Snijder, Markus G. Manz, Dario Neri
Izvirni znanstveni članek
Oznake: antibodies;dual-cytokine-antibody;CD38;multiple myeloma;TRAIL, IL2;
A novel dual-cytokine–antibody fusion protein, consisting of an antibody directed against CD38 [a tumor-associated antigen mainly expressed on the surface of multiple myeloma (MM) cells], simultaneously fused to both tumor necrosis factor ligand superfamily member 10 (TRAIL) and interleukin-2 (IL2), ...
Leto: 2018 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Ex vivo drug response heterogeneity reveals personalized therapeutic strategies for patients with multiple myeloma
Klara Kropivšek, Paul Kachel, Sandra Goetze, Rebekka Wegmann, Yasmin Festl, Yannik Severin, Benjamin D. Hale, Julien Mena, Audrey Van Drogen, Nadja Dietliker
Izvirni znanstveni članek
Oznake: ultiple myeloma;precision medicine;ex-vivo;pharmacoscopy;proteotyping;oncology;hematology;microscopy;drug score;
Abstract Multiple myeloma (MM) is a plasma cell malignancy defined by complex genetics and extensive patient heterogeneity. Despite a growing arsenal of approved therapies, MM remains incurable and in need of guidelines to identify effective personalized treatments. Here, we survey the ex vivo dr ...
Leto: 2023 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
P856
Klara Kropivšek, Paul Kachel, Sandra Goetze, Rebekka Wegmann, Yannik Severin, Benjamin D. Hale, Yasmin Festl, Julien Mena, Audrey Van Drogen, Nadja Dietliker
Objavljeni povzetek znanstvenega prispevka na konferenci
Oznake: mutliple myeloma;hematology;precision medicine;microscopy;deep learning;phenotyping;oncology;proteotype;
Multiple myeloma (MM) is a cancer of plasma cells, defined by complex genetics and extensive intra- and inter-patient heterogeneity. Despite improved patient survival driven by a plethora of treatment options, the disease remains incurable. Molecularly-guided precision medicine to individualize t ...
Leto: 2022 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Št. zadetkov: 3
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