Št. zadetkov: 49
Doktorska disertacija
Oznake:
Klopni meningoencefalitis;teža bolezni;postencefalitisni sindrom;imunski odziv;napovedni dejavniki;
Izhodišča. O dejavnikih, ki določajo, kakšna bosta potek in izid klopnega meningoencefalitisa (KME), o (dolgo)trajnih posledicah prebolele bolezni (postencefalitisni sindrom) in o mehanizmih, ki so povezani z neugodnim potekom in izidom bolezni, je malo znanega.
Namen. Namen raziskave je opredelit ...
Leto:
2019
Vir:
Medicinska fakulteta (UL MF)
Jan Slunečko,
Rok Kogoj,
Samo Zakotnik,
Alen Suljič,
Nataša Knap,
Martin Bosilj,
Franc Strle,
Tatjana Avšič-Županc,
Petra Bogovič,
Petra Bogovič,
Miša Korva,
Miša Korva
Izvirni znanstveni članek
Oznake:
mNGS;clinical metagenomics;molecular diagnostics;universal pathogen detection;enhanced RNA virus detection;
Introduction: Blood culture is the cornerstone of microbiological diagnostics for patients with acute undifferentiated fever and no obvious localization of infection; however, up to 50% of cases remain undiagnosed. Infections caused by arboviruses, fastidious or even uncultivable bacteria, or parasi ...
Leto:
2025
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Izvirni znanstveni članek
Oznake:
lyme borreliosis;immunocompromised host;TNF-[alpha] inhibitors;erythema migrans;treatment;outcome;
The study evaluated the course and outcome of erythema migrans in patients receiving tumour necrosis factor-alpha (TNF-α) inhibitors. Among 4157 adults diagnosed with erythema migrans in the period 2009–2018, 16 (2.6%) patients were receiving TNF-α inhibitors (adalimumab, infliximab, etarnecept, gol ...
Leto:
2019
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
SARS-CoV-2;nasopharyngeal swab;saliva;
A prospective cohort study was conducted during the Delta and Omicron severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) epidemic waves from paired nasopharyngeal swab (NPS or NP swab) and saliva samples taken from 624 participants. The study aimed to assess if any differences among p ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
COVID-19;dexamethasone;glucocorticoid pathway;methylprednisolone;polymorphism;treatment outcome;
Introduction: Corticosteroids are widely used for the treatment of coronavirus disease (COVID)-19. Genetic polymorphisms of the glucocorticoid receptor, metabolizing enzymes, or transporters may affect treatment response to dexamethasone. This study aimed to evaluate the association of the glucocort ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
hemorrhagic fever;vascular endothelial growth factor;soluble receptor;
Hemorrhagic fever with renal syndrome (HFRS) is characterized by endothelial dysfunction with capillary leakage without obvious cytopathology in the capillary endothelium. The aim of the study was to analyze the kinetics of vascular endothelial growth factor (VEGF) and its soluble receptor (sVEGFR-2 ...
Leto:
2018
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
tick-borne encephalitis;humoral immune response;serum IgG antibodies;course;outcome;
Tick-borne encephalitis (TBE) is associated with a range of disease severity. The reasons for this heterogeneity are not clear. Levels of serum IgG antibodies to TBE virus (TBEV) were determined in 691 adult patients during the meningoencephalitic phase of TBE and correlated with detailed clinical a ...
Leto:
2021
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
erythema migrans;Lyme borreliosis;Lyme disease;
Information on asplenic Lyme borreliosis (LB) patients with erythema migrans (EM) is lacking. We compared the course and outcome of 26 EM episodes in 24 post-trauma splenectomized patients (median age 51 years) diagnosed at a single clinical center in Slovenia during 1994–2023 with those of 52 age- ...
Leto:
2024
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Izvirni znanstveni članek
Oznake:
klopni encefalitis;cerebralna tekočina;citokini;imunski odziv;tick-borne encephalitis;monophasic course;biphasic course;long-term outcome;cerebrospinal fluid;cytokines;chemokines;innate immune responses;adaptive immune responses;
The biphasic course of tick-borne encephalitis (TBE) is well described, but information on the monophasic course is limited. We assessed and compared the clinical presentation, laboratory findings, and immune responses in 705 adult TBE patients: 283 with monophasic and 422 with biphasic course. Pati ...
Leto:
2021
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
tick-borne encephalitis virus;whole genome sequencing;metagenomics;
The clinical presentation of tick-borne encephalitis virus (TBEV) infection varies from asymptomatic to severe meningoencephalitis or meningoencephalomyelitis. The TBEV subtype has been suggested as one of the most important risk factors for disease severity, but TBEV genetic characterization is dif ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)