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Št. zadetkov: 6
Microbial volatiles as diagnostic biomarkers of bacterial lung infection in mechanically ventilated patients
Waqar Ahmed, Dominic Fenn, I. R. White, Breanna Dixon, Tamara M. E. Nijsen, Hugo Knobel, Paul Brinkman, Pouline M. van Oort, Marcus J. Schultz, Paul Dark
Izvirni znanstveni članek
Oznake: breath volatile;VOCs;infection;VAP;respiratory pathogens;
Background Early and accurate recognition of respiratory pathogens is crucial to prevent increased risk of mortality in critically ill patients. Microbial-derived volatile organic compounds (mVOCs) in exhaled breath could be used as non-invasive biomarkers of infection to support clinical diagnosis ...
Leto: 2023 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Detection and quantification of exhaled volatile organic compounds in mechanically ventilated patients
Pouline M. van Oort, I. R. White, Waqar Ahmed, Craig Johnson, Jonathan Bannard-Smith, Timothy Felton, Lieuwe D. Bos, Royston Goodacre, Paul Dark, Stephen J Fowler
Izvirni znanstveni članek
Oznake: volatile organic compounds;infection;breath;ventilator associated pneumonia;
Exhaled breath analysis is a promising new diagnostic tool, but currently no standardised method for sampling is available in mechanically ventilated patients. We compared two breath sampling methods, first using an artificial ventilator circuit, then in “real life” in mechanically ventilated patien ...
Leto: 2021 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Analysis of exhaled breath to identify critically ill patients with ventilator-associated pneumonia
T. W. Felton, Waqar Ahmed, I. R. White, Pouline M. van Oort, Nicholas J. W. Rattray, C. Docherty, Jonathan Bannard-Smith, J.B. Morton, Ingeborg Welters, R. McMullan
Izvirni znanstveni članek
Oznake: breath;diagnosis;ventilator-associated pneumonia;
Ventilator-associated pneumonia commonly occurs in critically ill patients. Clinical suspicion results in overuse of antibiotics, which in turn promotes antimicrobial resistance. Detection of volatile organic compounds in the exhaled breath of critically ill patients might allow earlier detection of ...
Leto: 2023 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Untargeted molecular analysis of exhaled breath as a diagnostic test for ventilator-associated lower respiratory tract infections (BreathDx)
Pouline M. van Oort, Tamara M. E. Nijsen, I. R. White, Hugo Knobel, Timothy Felton, Nicholas J. W. Rattray, Oluwasola Lawal, Murtaza Bulut, Waqar Ahmed, Antonio Artigas
Kratki znanstveni prispevek
Oznake: ventilator-associated pneumonia;breath analysis;volatile organic compounds;metabolomics;intensive care;hospital acquired infections;
Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with ...
Leto: 2021 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Composition and diversity analysis of the lung microbiome in patients with suspected ventilator-associated pneumonia
Dominic Fenn, Mahmoud I. Abdel-Aziz, Pouline M. van Oort, Paul Brinkman, Waqar Ahmed, Timothy Felton, Antonio Artigas, Pedro Póvoa, Ignacio Martin-Loeches, I. R. White
Izvirni znanstveni članek
Oznake: microbiome;next-generation sequencing;ventilator-associated pneumonia;
Background: Ventilator-associated pneumonia (VAP) is associated with high morbidity and health care costs, yet diagnosis remains a challenge. Analysis of airway microbiota by amplicon sequencing provides a possible solution, as pneumonia is characterised by a disruption of the microbiome. However, s ...
Leto: 2022 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Exhaled breath metabolomics reveals a pathogen-specific response in a rat pneumonia model for two human pathogenic bacteria
Pouline M. van Oort, Paul Brinkman, Gitte Slingers, Gudrun Koppen, Adrie Maas, Joris J. Roelofs, Ronny Schnabel, Dennis C. Bergmans, M. Raes, Royston Goodacre, Stephen J Fowler, Marcus J. Schultz, Lieuwe D. Bos, I. R. White
Izvirni znanstveni članek
Oznake: biomarkers;exhaled breath analysis;infection;pneumonia;
Volatile organic compounds in breath can reflect host and pathogen metabolism and might be used to diagnose pneumonia. We hypothesized that rats with Streptococcus pneumoniae (SP) or Pseudomonas aeruginosa (PA) pneumonia can be discriminated from uninfected controls by thermal desorption-gas chromat ...
Leto: 2019 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Št. zadetkov: 6
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