Št. zadetkov: 12
Video in druga učna gradiva
Oznake:
medicine;oncology
The enzyme isocytrate dehydrogenase IDH is very important in carbohydrate metabolism, and when mutated in cancer cells, the metabolic pathway is drastically altered. Somatic mutations in IDH1/2 occur in ~20% of patients with myeloid neoplasms, including glioma, melanoma, prostate cancer and acute my ...
Leto:
2018
Vir:
videolectures.net
Izvirni znanstveni članek
Oznake:
cancer genomics;cBioPortal;data mining;epigenetics;gene expression;in silico;
In biomedical research, large-scale profiling of gene expression has become routine and offers a valuable means to evaluate changes in onset and progression of diseases, in particular cancer. An overwhelming amount of cancer genomics data has become publicly available, and the complexity of these da ...
Leto:
2019
Vir:
Nacionalni inštitut za biologijo (NIB)
Kratki znanstveni prispevek
Oznake:
glioblastoma;matične celice;akutna mielonična levkemija;kostni mozeg;glioblastoma stem cells;niches;acute myeloid leukemia;hematopoietic stem cells;bone marrow;C-X-C receptor type 4;stromal-derived factor-1 ▫$[alpha]$▫;plerixafor;
Glioblastoma is the most aggressive and malignant primary brain tumor in adults and has a poor patient survival of only 20 months after diagnosis. This poor patient survival is at least partly caused by glioblastoma stem cells (GSCs), which are slowly-dividing and therefore therapy-resistant. GSCs a ...
Leto:
2020
Vir:
Nacionalni inštitut za biologijo (NIB)
Pregledni znanstveni članek
Oznake:
green tea;glioma;
The review discusses the effects of Epigallocatechin-3-gallate Gallate (EGCG) on glioma as a basis for future research on clinical application of EGCG. Epidemiological studies on the effects of green tea or EGCG on the risk of glioma is inconclusive due to the limited number of studies, the inclusio ...
Leto:
2018
Vir:
Nacionalni inštitut za biologijo (NIB)
Pregledni znanstveni članek
Oznake:
glioblastoma;endotelne celice;tumorsko mikrookrožje;hipoksija;glioma stem cells;niches;blood vessels;extracellular matrix;tumor microenvironment;hypoxia;therapy resistance;vasculature;
Glioblastoma is the most lethal primary brain tumor and poor survival of glioblastoma patients is attributed to the presence of glioma stem cells (GSCs). These therapy-resistant, quiescent and pluripotent cells reside in GSC niches, which are specific microenvironments that protect GSCs against radi ...
Leto:
2018
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
2D transwell invasion assay;3D spheroid invasion assay;cancer cell;cellular invasion;glioblastoma stem cells;
Invasion is a hallmark of cancer and therefore in vitro invasion assays are important tools in cancer research. We aimed to describe in vitro 2D transwell assays and 3D spheroid assays to quantitatively determine the invasive behavior of glioblastoma stem cells in response to the chemoattractant SDF ...
Leto:
2020
Vir:
Nacionalni inštitut za biologijo (NIB)
Pregledni znanstveni članek
Oznake:
medicinske znanosti;levkemija;zdravljenje;terapevtske strategije;hematopoietic stem cell niche;hijacking;leukemic stem cells;bone marrow;therapy resistance;leukemia;
Acute myeloid leukemia and acute lymphoblastic leukemia cells hijack hematopoietic stem cell (HSC) niches in the bone marrow and become leukemic stem cells (LSCs) at the expense of normal HSCs. LSCs are quiescent and resistant to chemotherapy and can cause relapse of the disease. HSCs in niches are ...
Leto:
2017
Vir:
Nacionalni inštitut za biologijo (NIB)
Pregledni znanstveni članek
Oznake:
glioblastoma stem cells;IDH1-mutation;energy metabolism;
Cancer is a redox disease. Low levels of reactive oxygen species (ROS) are beneficial for cells and have anti-cancer effects. ROS are produced in the mitochondria during ATP production by oxidative phosphorylation (OXPHOS). In the present review, we describe ATP production in primary brain tumors, g ...
Leto:
2021
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
immunohistochemistry;chromogens;aminoethyl carbazole;AEC;3,3'-diaminobenzidine;DAB;antigen retrieval;tonsil;
Immunohistochemistry (IHC) specifically localizes proteins in cells and tissues, but methodologies vary widely. Therefore, we performed a methodological IHC optimization and validation study. First, we compared advantages and disadvantages of cryostat sections versus paraffin sections. Second, we co ...
Leto:
2019
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
izocitrat dehidrogenaza;PARP;hipertemija;D‐2‐hidroksiglutarat;radioterapija;cisplatin;isocitrate dehydrogenase;hyperthermia;D‐2‐hydroxyglutarate;radiotherapy;
Mutations in the isocitrate dehydrogenase 1 (IDH1MUT) gene occur in various types of malignancies, including ~60% of chondrosarcomas, ~30% of intrahepatic cholangiocarcinomas and >80% of low-grade gliomas. IDH1MUT are causal in the development and progression of these types of cancer due to neomorph ...
Leto:
2022
Vir:
Nacionalni inštitut za biologijo (NIB)