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Št. zadetkov: 2
Cytokine CCL5 and receptor CCR5 axis in glioblastoma multiforme
Miha Koprivnikar Krajnc, Metka Novak, Richard G. Pestell, Tamara Lah Turnšek
Pregledni znanstveni članek
Oznake: cytokines;CCL5-RANTES;glioblastoma;tumour microenvironment;mesenchymal stem cells;signalling;
Background Glioblastoma is the most frequent and aggressive brain tumour in humans with median survival from 12 to 15 months after the diagnosis. This is mostly due to therapy resistant glioblastoma stem cells in addition to intertumour heterogeneity that is due to infiltration of a plethora of hos ...
Leto: 2019 Vir: Nacionalni inštitut za biologijo (NIB)
CCR5-mediated signaling is involved in invasion of glioblastoma cells in its microenvironment
Metka Novak, Miha Koprivnikar Krajnc, Barbara Hrastar, Barbara Breznik, Bernarda Majc, Mateja Mlinar, Ana Rotter, Andrej Porčnik, Jernej Mlakar, Katja Stare, Richard G. Pestell, Tamara Lah Turnšek
Izvirni znanstveni članek
Oznake: glioblastom;kemokini;tumorsko mikrookolje;invazija;CCL5;CCR5;chemokines;glioblastoma;invasion;maraviroc;mesenchymal stem cells;
Abstract The chemokine CCL5/RANTES is a versatile inflammatory mediator, which interacts with the receptor CCR5, promoting cancer cell interactions within the tumor microenvironment. Glioblastoma is a highly invasive tumor, in which CCL5 expression correlates with shorter patient survival. Using im ...
Leto: 2020 Vir: Nacionalni inštitut za biologijo (NIB)
Št. zadetkov: 2
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