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Št. zadetkov: 3
Autoimmunity to synovial extracellular matrix proteins in patients with postinfectious Lyme arthritis
Korawit Kanjana, Klemen Strle, Robert B. Lochhead, Annalisa Pianta, Laura M. Mateyka, Qi Wang, Sheila Arvikar, David E. Kling, Cameron A. Deangelo, Lucy Curham
Izvirni znanstveni članek
Oznake: Lyme arthritis;autoimmune diseases;infectious disease;
Background. Autoimmune diseases often have strong genetic associations with specific HLA-DR alleles. The synovial lesion in chronic inflammatory forms of arthritis shows marked upregulation of HLA-DR molecules, including in postinfectious Lyme arthritis (LA). However, the identity of HLA-DR–presente ...
Leto: 2023 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
HLA-DR–expressing fibroblast-like synoviocytes are inducible antigen presenting cells that present autoantigens in Lyme arthritis
Joseph R. Rouse, Rebecca Danner, Amanda Wahhab, Michaela Pereckas, Christine Nguyen, Mecaila E. McClune, Allen C. Steere, Klemen Strle, Brandon L. Jutras, Robert B. Lochhead
Izvirni znanstveni članek
Oznake: Lyme arthritis;autoimmune diseases;infectious disease;
Objective: HLA-DR–expressing fibroblast-like synoviocytes (FLS) are a prominent cell type in synovial tissue in chronic inflammatory forms of arthritis. FLS-derived extracellular matrix (ECM) proteins, including fibronectin-1 (FN1), contain immunogenic CD4+ T cell epitopes in patients with postinfec ...
Leto: 2024 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Peptidoglycan in osteoarthritis synovial tissue is associated with joint inflammation
Meaghan N Holub, Amanda Wahhab, Joseph R. Rouse, Rebecca Danner, Lauren G Hackner, Christine B Duris, Mecaila E. McClune, Jules M Dressler, Klemen Strle, Brandon L. Jutras, Adam I Edelstein, Robert B. Lochhead
Izvirni znanstveni članek
Oznake: osteoarthritis;peptidoglycan;synovitis;inflammation;
Objectives: Peptidoglycan (PG) is an arthritogenic bacterial cell wall component whose role in human osteoarthritis is poorly understood. The purpose of this study was to determine if PG is present in synovial tissue of osteoarthritis patients at the time of primary total knee arthroplasty (TKA), an ...
Leto: 2024 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Št. zadetkov: 3
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