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Št. zadetkov: 2
Action of clathrodin and analogues on voltage-gated sodium channels
Steve Peigneur, Aleš Žula, Nace Zidar, Fiona Chan-Porter, Robert Kirby, David J. Madge, Janez Ilaš, Danijel Kikelj, Jan Tytgat
Izvirni znanstveni članek
Oznake: oroidin;hymenidin;clathrodin;voltage-gated sodium channels;sodium channel modulator;sponge;
Clathrodin is a marine alkaloid and believed to be a modulator of voltage-gated sodium (NaV) channels. Since there is an urgent need for small molecule NaV channel ligands as novel therapeutics, clathrodin could representan interesting lead compound. Therefore, clathrodin was reinvestigated for its ...
Leto: 2014 Vir: Fakulteta za farmacijo (UL FFA)
New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel
Nace Zidar, Tihomir Tomašić, Danijel Kikelj, Martina Durcik, Jan Tytgat, Marc Rogers, Alexander Haworth, Robert W. Kirby
Izvirni znanstveni članek
Oznake: napetostno odvisni natrijev kanal;Nav kanal;Nav1.3;zaviralci;arilsulfonamid;acilsulfonamid;Voltage-gated sodium channel;Nav channel;inhibitor;arylsulfonamide;acylsulfonamide;
Voltage-gated sodium channels (Navs) play an essential role in neurotransmission, and their dysfunction is often a cause of various neurological disorders. The Nav1.3 isoform is found in the CNS and upregulated after injury in the periphery, but its role in human physiology has not yet been fully el ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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