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Št. zadetkov: 6
Comparison of ex vivo and in vitro human fibroblast ageing models
Federica Boraldi, Giulia Annovi, Roberta Tiozzo, Pascal Sommer, Daniela Quaglino
Izvirni znanstveni članek
Oznake: ageing;fibroblast;connective tissue;oxidative stress;protein expression;elastin;
Several studies have analyzed modulation of gene expression during physiological ageing with interesting, but often contradictory results, depending on the model used. In the present report we compare age-related metabolic and synthetic parameters in human dermal fibroblasts (HDF) isolated from youn ...
Leto: 2010 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
ǂThe ǂeffect of serum withdrawal on the protein profile of quiescent human dermal fibroblasts in primary cell culture
Federica Boraldi, Giulia Annovi, Chiara Paolinelli DeVincenzi, Roberta Tiozzo, Daniela Quaglino
Izvirni znanstveni članek
Oznake: dermal fibroblasts;primary cell culture;ROS production;serum withdrawal;
The effect of serum deprivation on proliferating cells is well known, in contrast its role on primary cell cultures, at confluence, has not been deeply investigated. Therefore, in order to explore the response of quiescent cells to serum deprivation, ubiquitous mesenchymal cells, as normal human ...
Leto: 2008 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Hypoxia influences the cellular cross-talk of human dermal fibroblasts
Federica Boraldi, Giulia Annovi, Fabio Carraro, Antonella Naldini, Roberta Tiozzo, Pascal Sommer, Daniela Quaglino
Izvirni znanstveni članek
Oznake: human fibroblast;primary cell cultur;hypoxia;connective tissue;proteome;2D gel electrophoresis;mass-spectrometry;
The ability of cells to respond to changes in oxygen availability is critical for many physiological and pathological processes (i.e. development, aging, wound healing, hypertension, cancer). Changes in the protein profile of normal human dermal fibroblasts were investigated in vitro after 96 h in ...
Leto: 2007 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Heparan sulfate affects elastin deposition in fibroblasts cultured from donors of different ages
Giulia Annovi, Federica Boraldi, Pasquale Moscarelli, Deanna Guerra, Roberta Tiozzo, Bruna Parma, Pascal Sommer, Daniela Quaglino
Izvirni znanstveni članek
Oznake: heparan sulfate;elastin;fibroblasts;
Heparan sulfate (HS), due to its presence on the cell surface and in the extracellular milieu and its ability to modulate cell signaling, has a fundamental role in both physiological and pathological conditions. For decades we have demonstrated the occurrence of interactions between glycosaminogly ...
Leto: 2012 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Matrix gla protein and alkaline phosphatase are differently modulated in human dermal fibroblasts from PXE patients and controls
Federica Boraldi, Giulia Annovi, Cees Vermeer, Leon J. Schurgers, Tommaso Trenti, Roberta Tiozzo, Deanna Guerra, Daniela Quaglino
Izvirni znanstveni članek
Oznake: fibroblast;vitamin K;elastin calcification;proteomics;
Matrix Gla Protein and Alkaline Phosphatase Are Differently Modulated in Human Dermal Fibroblasts from PXE Patients and Controls
Leto: 2013 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Fibroblast protein profile analysis highlights the role of oxidative stress and vitamin K recycling in the pathogenesis of pseudoxanthoma elasticum
Federica Boraldi, Giulia Annovi, Deanna Guerra, Chiara Paolinelli DeVincenzi, Maria Inmaculada Garcia-Fernandez, Fulvio Panico, Giorgio De Santis, Roberta Tiozzo, Ivonne Pasquali Ronchetti, Daniela Quaglino
Izvirni znanstveni članek
Oznake: ectopic calcification;elastin;fibroblast proteome;MRP6;PXE;
Pseudoxanthoma elasticum (PXE) is a genetic disorder associated to mutations in the ABCC6 gene; however, the pathogenetic mechanisms leading to elastic fibre calcifications and to clinical manifestations are still unknown. Dermal fibroblasts, directly involved in the production of the extracellular ...
Leto: 2009 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Št. zadetkov: 6
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