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Št. zadetkov: 3
Vpliv internega komuniciranja na delovno uspešnost
Rok Grahek, Cirila Toplak
Diplomsko delo
Oznake: Organizacijsko komuniciranje;Komuniciranje;Skupine;Uspeh;Zaposleni;Employees;Diplomska dela;
Vpliv internega komuniciranja na delovno uspešnost
Leto: 2016 Vir: Fakulteta za družbene vede (UL FDV)
NDMA formation due to active ingredient degradation and nitrite traces in drug product
Nejc Golob, Simona Peterlin, Rok Grahek, Robert Roškar
Izvirni znanstveni članek
Oznake: N-nitrozodimetilamin (NDMA);zdravilo afatinib;razgradnja zdravilne učinkovine;dimetilamin (DMA);nitriti;pomožne snovi;krospovidon;stabilnostne študije;N-nitrosodimethylamine (NDMA);afatinib drug product;drug substance degradation;dimethylamine (DMA);nitrite;excipient;crospovidone;stability study;
N-nitrosamines are genotoxic compounds which can be found as impurities in drug substances and drug products used in the pharmaceutical industry. To date, several possible nitrosamine sources in drug products have been reported and this study aims to illuminate another one. A case of afatinib drug p ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Stability and degradation pathways of N-nitroso-hydrochlorothiazide and the corresponding aryl diazonium ion
Rok Grahek, Miha Drev, Borut Zupančič, Jure Hren, Matej Ošlaj, Andrej Bastarda, Andrej Kocijan, Zdenko Časar
Izvirni znanstveni članek
Oznake: hydrochlorothiazide;N-nitrosamine;thiatriazine;diazonium;
Despite the fact that it was put on the market more than 60 years ago, hydrochlorothiazide (HCT) is still one of the most important antihypertensive drugs. Due to its chemical structure, which contains the secondary aryl-alkyl-amino moiety, it is vulnerable to the formation of N-nitrosamine drug sub ...
Leto: 2023 Vir: Repozitorij Univerze v Ljubljani (RUL)
Št. zadetkov: 3
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