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Št. zadetkov: 2
Study by molecular dynamics simulations of the nuclear receptor protein PPAR[gamma]
Filip Cernatič, Roland H. Stote, Črtomir Podlipnik, Franc Požgan, Miha Lukšič
Magistrsko delo
Oznake: nuclear receptor;PPARgamma;CDK5;phosphorylation;molecular dynamics;
PPARγ is a nuclear receptor protein that has a central role in promoting adipocyte growth and differentiation, as well as regulating serum glucose and triglyceride levels. Under normal physiological conditions, PPARγ is a target of several post-translational modifications (PTMs) that modulate its tr ...
Leto: 2020 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Computational design of 4-azido-L-alanine-incorporating non-ribosomal peptide synthetase
Vid Dobrovoljc, Barbara Hribar, Roland H. Stote, Matija Strlič, Tomaž Urbič
Magistrsko delo
Oznake: non-ribosomal peptidyl synthases;computational design of multipoint active site mutants;FuncLib tool;MMPBSA method;
Non-ribosomal peptidyl synthases (NRPS) are huge multimodular megaenzymes. Each of their modules incorporates one monomer, and that is how they synthesize a very diverse range of products in an assembly line fashion. The adenylation (A) domain was recognized very early on as a 'specificity guard' of ...
Leto: 2025 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Št. zadetkov: 2
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