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Protein formulations containing polysorbates
Ema Valentina Brovč, Stane Pajk, Roman Šink, Janez Mravljak
Izvirni znanstveni članek
Oznake: proteins;oxidation;Fenton reaction;free radicals;chelating agents;polysorbates;
Proteins are prone to post-translational modifications at specific sites, which can affect their physicochemical properties, and consequently also their safety and efficacy. Sources of post-translational modifications include oxygen and reactive oxygen species. Additionally, catalytic amounts of Fe( ...
Leto: 2020 Vir: Fakulteta za farmacijo (UL FFA)
Alternative buffer systems in biopharmaceutical formulations and their effect on protein stability
Blaž Lebar, Mitja Zidar, Janez Mravljak, Roman Šink, Aleš Žula, Stane Pajk
Izvirni znanstveni članek
Oznake: biopharmaceuticals;buffer;stress;aggregates;alternative buffers;stability;
The formulation of biopharmaceutical drugs is designed to eliminate chemical instabilities, increase conformational and colloidal stability of proteins, and optimize interfacial stability. Among the various excipients involved, buffer composition plays a pivotal role. However, conventional buffers l ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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