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Št. zadetkov: 2
Pharmacokinetic-pharmacodynamic model of vedolizumab for targeting endoscopic remission in patients with crohn disease
Jurij Hanžel, Erwin Dressen, Séverine Vermeire, Mark Löwenberg, Frank Hoentjen, Peter Bossuyt, Esmé Clasquin, Filip J. Baert, Geert R. D'Haens, Ron Mathôt
Izvirni znanstveni članek
Oznake: farmakometrika;kronična vnetna črevesna bolezen;vedolizumab;Crohnova bolezen;
Background: Higher serum concentrations of vedolizumab have been associated with improved outcomes in inflammatory bowel disease. It is unclear how vedolizumab exposure is linked to endoscopic remission in Crohn disease (CD). We aimed to develop a pharmacokinetic-pharmacodynamic model linking vedoli ...
Leto: 2022 Vir: Medicinska fakulteta (UL MF)
ǂA ǂphase Ib clinical trial of metformin and chloroquine in patients with IDH1-mutated solid tumors
Mohammed Khurshed, Remco J. Molenaar, Myra E van Linde, Ron Mathôt, Eduard A. Struys, Tom van Wezel, Cornelis J. F. van Noorden, Heinz-Josef Klümpen, Judith V. M. G. Bovée, Johanna W Wilmink
Izvirni znanstveni članek
Oznake: metformin;chloroquine;cancer;isocitrate dehydrogenase;pharmacokinetics;glioblastoma;intrahepatic cholangiocarcinoma;chondrosarcoma;
Background: Mutations in isocitrate dehydrogenase 1 (IDH1) occur in 60% of chondrosarcoma, 80% of WHO grade II-IV glioma and 20% of intrahepatic cholangiocarcinoma. These solid IDH1-mutated tumors produce the oncometabolite D-2-hydroxyglutarate (D-2HG) and are more vulnerable to disruption of their ...
Leto: 2021 Vir: Nacionalni inštitut za biologijo (NIB)
Št. zadetkov: 2
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