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Št. zadetkov: 10
Effects of high relative humidity and dry purging on VOCs obtained during breath sampling on common sorbent tubes
Maxim Wilkinson, I. R. White, Royston Goodacre, Tamara M. E. Nijsen, Stephen J Fowler
Izvirni znanstveni članek
Oznake: VOCs;breath sampling;ReCIVA;
Offline breath analysis by thermal desorption gas chromatography mass spectrometry (TD-GC-MS) requires the use of sorbent traps to concentrate and store volatile compounds. The selection of which sorbent to use and best practices for managing high relative humidity are important considerations to al ...
Leto: 2020 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Headspace volatile organic compounds from bacteria implicated in ventilator-associated pneumonia analysed by TD-GC/MS
Oluwasola Lawal, Howbeer Muhamadali, Waqar Ahmed, I. R. White, Tamara M. E. Nijsen, Royston Goodacre, Stephen J Fowler
Izvirni znanstveni članek
Oznake: bacteria;exhaled breath;infection;ventilator-associated pneumonia;volatile organic compounds;
Ventilator-associated pneumonia (VAP) is a healthcare-acquired infection arising from the invasion of the lower respiratory tract by opportunistic pathogens in ventilated patients. The current method of diagnosis requires the culture of an airway sample such as bronchoalveolar lavage, which is invas ...
Leto: 2018 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
TD/GC-MS analysis of volatile markers emitted from mono- and co-cultures of Enterobacter cloacae and Pseudomonas aeruginosa in artificial sputum
Oluwasola Lawal, Hugo Knobel, Hans Weda, Tamara M. E. Nijsen, Royston Goodacre, Stephen J Fowler, I. R. White
Izvirni znanstveni članek
Oznake: bacteria;Enterobacter cloacae;gas chromatography-mass spectrometry;infection;Pseudomonas aeruginosa;volatile organic compounds;
Introduction: Infections such as ventilator-associated pneumonia (VAP) can be caused by one or more pathogens. Current methods for identifying these pathogenic microbes often require invasive sampling, and can be time consuming, due to the requirement for prolonged cultural enrichment along with sel ...
Leto: 2018 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
ǂA ǂmicrobiome and metabolomic signature of phases of cutaneous healing identified by profiling sequential acute wounds of human skin
Mohammed Ashrafi, Yun Xu, Howbeer Muhamadali, I. R. White, Maxim Wilkinson, Katherine Hollywood, Mohamed Baguneid, Royston Goodacre, Ardeshir Bayat
Izvirni znanstveni članek
Oznake: metabolomics;skin;volatile organic compounds;VOCs;wound healing;
Profiling skin microbiome and metabolome has been utilised to gain further insight into wound healing processes. The aims of this multi-part temporal study in 11 volunteers were to analytically profile the dynamic wound tissue and headspace metabolome and sequence microbial communities in acute woun ...
Leto: 2020 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Circadian rhythm of exhaled biomarkers in health and asthma
Maxim Wilkinson, Robert Maidstone, Andrew Loudon, John Blaikley, I. R. White, Dave Singh, David Ray Webb, Royston Goodacre, Stephen J Fowler, Hannah J. Durrington
Kratki znanstveni prispevek
Oznake: astma;cirkadiani ritem;dihanje;
Circadian rhythms control many biological processes in the body in both health and disease. Greater understanding of diurnal variability in disease related biomarkers is crucial for their application in clinical practice and biomarkers of circadian rhythm are required to facilitate further research ...
Leto: 2019 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Breath and plasma metabolomics to assess inflammation in acute stroke
Waqar Ahmed, I. R. White, Maxim Wilkinson, Craig Johnson, Nicholas J. W. Rattray, Amit K. Kishore, Royston Goodacre, Craig J. Smith, Stephen J Fowler
Izvirni znanstveni članek
Oznake: stroke;metabolomics;breath;VOCs;inflammation;
Inflammation is strongly implicated in both injury and repair processes occurring after stroke. In this exploratory study we assessed the feasibility of repeated sampling of exhaled volatile organic compounds and performed an untargeted metabolomic analysis of plasma collected at multiple time perio ...
Leto: 2021 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Development of an adaptable headspace sampling method for metabolic profiling of the fungal volatome
Waqar Ahmed, Pavlos Geranios, I. R. White, Oluwasola Lawal, Tamara M. E. Nijsen, Michael J. Bromley, Royston Goodacre, Nick Duncan Read, Stephen J Fowler
Izvirni znanstveni članek
Oznake: volatile organic compounds;fungi;mycelial growth;
Pulmonary aspergillosis can cause serious complications in people with a suppressed immune system. Volatile metabolites emitted by Aspergillus spp. have shown promise for early detection of pathogenicity. However, volatile profiles require further research, as effective headspace analysis methods ar ...
Leto: 2018 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Detection and quantification of exhaled volatile organic compounds in mechanically ventilated patients
Pouline M. van Oort, I. R. White, Waqar Ahmed, Craig Johnson, Jonathan Bannard-Smith, Timothy Felton, Lieuwe D. Bos, Royston Goodacre, Paul Dark, Stephen J Fowler
Izvirni znanstveni članek
Oznake: volatile organic compounds;infection;breath;ventilator associated pneumonia;
Exhaled breath analysis is a promising new diagnostic tool, but currently no standardised method for sampling is available in mechanically ventilated patients. We compared two breath sampling methods, first using an artificial ventilator circuit, then in “real life” in mechanically ventilated patien ...
Leto: 2021 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Exhaled breath metabolomics reveals a pathogen-specific response in a rat pneumonia model for two human pathogenic bacteria
Pouline M. van Oort, Paul Brinkman, Gitte Slingers, Gudrun Koppen, Adrie Maas, Joris J. Roelofs, Ronny Schnabel, Dennis C. Bergmans, M. Raes, Royston Goodacre, Stephen J Fowler, Marcus J. Schultz, Lieuwe D. Bos, I. R. White
Izvirni znanstveni članek
Oznake: biomarkers;exhaled breath analysis;infection;pneumonia;
Volatile organic compounds in breath can reflect host and pathogen metabolism and might be used to diagnose pneumonia. We hypothesized that rats with Streptococcus pneumoniae (SP) or Pseudomonas aeruginosa (PA) pneumonia can be discriminated from uninfected controls by thermal desorption-gas chromat ...
Leto: 2019 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty
Nicholas J. W. Rattray, Drupad K. Trivedi, Yun Xu, Tarani Chandola, Caroline H. Johnson, Alan D. Marshall, Krisztina Mekli, Zahra Rattray, Gindo Tampubolon, Bram Vanhoutte, I. R. White, Frederick C. W. Wu, Neil Pendleton, James Y. Nazroo, Royston Goodacre
Izvirni znanstveni članek
Oznake: metabolomics;frailty;ageing;LC-MS;serum;
Global ageing poses a substantial economic burden on health and social care costs. Enabling a greater proportion of older people to stay healthy for longer is key to the future sustainability of health, social and economic policy. Frailty and associated decrease in resilience plays a central role in ...
Leto: 2019 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Št. zadetkov: 10
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