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Št. zadetkov: 2
Why and How to Control P-Chirality in Phosphorothioated Therapeutic Oligonucleotides
Tanja Poredoš, Marko Trampuž, Tjaša Gornik, Klemen Naveršnik, Maša Sinreih, Samo Pirc, Zdenko Časar
Pregledni znanstveni članek
Oznake: biopolymers;genetics;molecular structure;therapeutics;
A surge in the approval of therapeutic oligonucleotides since 2016 has made this class of chemical modalities an essential toolbox for addressing unmet medical needs in the realm of rare or difficult-to-treat diseases. Therapeutic oligonucleotides are complex drugs, primarily due to the active pharm ...
Leto: 2024 Vir: Repozitorij Univerze v Ljubljani (RUL)
High burden of clonal mast cell disorders and hereditary α-[alpha]tryptasemia in patients who need Hymenoptera venom immunotherapy
Julij Šelb, Matija Rijavec, Lisa Arzt-Gradwohl, Urban Čerpes, Grzegorz Porebski, Branko Pevec, Eva Schadelbauer, Peter Kopač, Samo Zver, Matevž Škerget, Ewa Czarnobilska, Wojciech Dyga, Sanja Popović-Grle, Miroslav Samaržija, Mitja Košnik, Mihaela Zidarn, Mark Kačar, Nina Frelih, Nika Lalek, Ajda Demšar Luzar, Peter Korošec, Gunter J. Sturm, Jonathan J. Lyons, Tinkara Pirc Marolt, Manca Svetina
Izvirni znanstveni članek
Oznake: anaphylaxis;hereditary α-tryptasemia;hypersensitivity;immunotherapy;mast cell;mastocytosis;venom;
Background In patients who require venom immunotherapy (VIT), there is a need to identify underlying mast cell (MC) disorders since these may affect the risk and severity of future sting reactions and the long-term effectiveness of VIT. Methods 1319 individuals with Hymenoptera venom allergy (H ...
Leto: 2024 Vir: Repozitorij Univerze v Ljubljani (RUL)
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