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Structural and functional determinants of TDP-43 aggregation
Sanja Škaro, Marco Baralle
Doktorska disertacija
Oznake: TDP-43 structural determinants;hybrid peptides;protein-protein interactions;intramolecular interaction;cation-π interaction;Drosophila orthologues.;
TDP-43 (TAR DNA-binding protein) is an hnRNP that was identified as the main component of the brain inclusions characteristically found in patients suffering of Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration. As an hnRNP protein, TDP-43 fulfills diverse roles in mRNA metabolism, ...
Leto: 2019 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
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