Št. zadetkov: 12
Magistrsko delo
Oznake:
neinvaziven presejalni test;DNA;različna metilacija;imunoprecipitacija;neinvazivna diagnostika;validacija testov;
Validacija neinvazivnega presejalnega testa za odkrivanje Downovega sindroma iz polne krvi nosečnic
Leto:
2015
Vir:
Fakulteta za farmacijo (UL FFA)
Doktorska disertacija
Oznake:
dopaminski agonisti;terapevtska uporaba;genetska variabilnost;dopaminergične poti;vnetne poti;oksidativni stres;apoptoza;nevroni;diferenciacija;
Introduction
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. The main pathological hallmark is the death of dopaminergic neurons in the nigrostriatal pathway, which mainly affects motor function. Therefore dopamine replacement strategy has a central role in PD manage ...
Leto:
2019
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
Parkinson's disease;polymorphism;pharmacogenetics;
Background: The most common psychiatric complications due to dopaminergic treatment in Parkinson's disease are visual hallucinations and impulse control disorders. Their development depends on clinical and genetic factors.Methods: We evaluated the simultaneous effect of 16 clinical and 34 genetic va ...
Leto:
2020
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
Parkinsonova bolezen;motorični zapleti;vizualne halucinacije;Parkinson’s disease;motor complications;visual hallucinations;
The serotonergic system is important in Parkinson’s disease (PD) pathogenesis as it can take over dopamine production after a large portion of dopaminergic neurons is lost through neurodegeneration. The aim of this study was to evaluate the effect of genetic variability of serotonergic genes on the ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
nevrologija;Parkinsonova bolezen;receptor vitamina D;nevroznanost;
Vitamin D is a lipid-soluble molecule and an important transcriptional regulator in many tissues and organs, including the brain. Its role has been demonstrated also in Parkinson’s disease (PD) pathogenesis. Vitamin D receptor (VDR) is responsible for the initiation of vitamin D signaling cascade. T ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
COVID-19;neurodegeneration;Alzheimer’s disease;
Introduction: Development and worsening of most common neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis, have been associated with COVID-19 However, the mechanisms associated with neurological symptoms in COVID-19 patients and neurodegenerative seq ...
Leto:
2023
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
Parkinson's disease;telomere length;levodopa treatment;
Telomeres, which are repetitive sequences that cap the end of the chromosomes, shorten with each cell division. Besides cellular aging, there are several other factors that influence telomere length (TL), in particular, oxidative stress and inflammation, which play an important role in the pathogene ...
Leto:
2021
Vir:
Medicinska fakulteta (UL MF)
Objavljeni znanstveni prispevek na konferenci
Oznake:
rak dojk;obsevanje;onkološko zdravljenje;
Obsevanje je del standardnega zdravljenja bolnic z rakom dojk. Odgovor na zdravljenje z obsevanjem je pri vsakem posamezniku drugačen in je odvisen tudi od genetskih dejavnikov. Eden od novejših genetskih označevalcev odgovora na obsevanje je dolžina telomerov. Telomeri ščitijo kromosome pred krajša ...
Leto:
2023
Vir:
Onkološki inštitut Ljubljana (OI)
Pregledni znanstveni članek
Oznake:
COVID-19;oksidativni stres;genetika;oxidative stress;genetics;
The coronavirus disease (COVID-19) pandemic is a leading global health and economic challenge. What defines the disease’s progression is not entirely understood, but there are strong indications that oxidative stress and the defense against reactive oxygen species are crucial players. A big influx o ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
Parkinson's Disease;genetic polymorphism;dopaminergic pathway;personalized medicine;adverse events;
Dopaminergic pathway is the most disrupted pathway in the pathogenesis of Parkinson's disease. Several studies reported associations of dopaminergic genes with the occurrence of adverse events of dopaminergic treatment. However, none of these studies adopted a pathway based approach. The aim of this ...
Leto:
2019
Vir:
Medicinska fakulteta (UL MF)