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Št. zadetkov: 2
Selpercatinib in RET fusion-positive non-small-cell lung cancer (SIREN)
Oliver Illini, Maximilian J Hochmair, Hannah Fabikan, Christoph Weinlinger, Amanda Tufman, Aurélie Swalduz, Kristina Lamberg, Sayed M. S. Hashemi, Florian Huemer, Anders Vikström, Katja Mohorčič
Izvirni znanstveni članek
Oznake: podatki iz resničnega življenja;selperactinib;tarčna terapija;zaviralci tirozinskih kinaz;real-world data;selpercatinib;targeted therapy;tyrosine kinase inhibitor;
Introduction: Rearranged during transfection (RET) gene fusions are rare genetic drivers in non-small cell lung cancer (NSCLC). Selective RET-inhibitors such as selpercatinib have shown therapeutic activity in early clinical trials; however, their efficacy in the real-world setting is unknown. Metho ...
Leto: 2021 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Mobocertinib in patients with EGFR exon 20 insertion-positive non-small cell lung cancer (MOON)
Oliver Illini, Felix Carl Saalfeld, Petros Christopoulos, Michaël Duruisseaux, Anders Vikström, Nir Peled, Ingel Demedts, Elizabeth Dudnik, Anna Eisert, Urška Janžič, Katja Mohorčič, Marija Ivanović, Sayed M. S. Hashemi
Izvirni znanstveni članek
Oznake: medicina;non-small cell lung cancer;EGFR exon 20 inhibitors;mobocertinib;real-world data;exon 20 insertion;
EGFR exon 20 (EGFR Ex20) insertion mutations in non-small cell lung cancer (NSCLC) are insensitive to traditional EGFR tyrosine kinase inhibitors (TKIs). Mobocertinib is the only approved TKI specifically designed to target EGFR Ex20. We performed an international, real-world safety and efficacy ana ...
Leto: 2024 Vir: Repozitorij Univerze v Ljubljani (RUL)
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