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Št. zadetkov: 2
Autoimmunity to synovial extracellular matrix proteins in patients with postinfectious Lyme arthritis
Korawit Kanjana, Klemen Strle, Robert B. Lochhead, Annalisa Pianta, Laura M. Mateyka, Qi Wang, Sheila Arvikar, David E. Kling, Cameron A. Deangelo, Lucy Curham
Izvirni znanstveni članek
Oznake: Lyme arthritis;autoimmune diseases;infectious disease;
Background. Autoimmune diseases often have strong genetic associations with specific HLA-DR alleles. The synovial lesion in chronic inflammatory forms of arthritis shows marked upregulation of HLA-DR molecules, including in postinfectious Lyme arthritis (LA). However, the identity of HLA-DR–presente ...
Leto: 2023 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Toll-like receptor 1 polymorphism is associated with impaired immune tolerance, dysregulated inflammatory responses to Borrelia burgdorferi, and heightened risk of post-infectious Lyme arthritis
Morgan A. Williams, Sergio A. Hernández, Sheila Arvikar, Katherine B. Sulka, Franc Strle, Christopher C. Wells, Tanja Petnicki-Ocwieja, Allen C. Steere, Klemen Strle
Izvirni znanstveni članek
Oznake: Lyme disease;Borrelia burgdorferi;toll-like receptors;innate immune tolerance;inflammation;Lyme arthritis;innate immunology;
Introduction: Clinical presentation of Lyme disease is largely due to host immune response to infection. Previously, we identified a variant (1805GG) in the TLR1 gene, a key immune sensor for Borrelia burgdorferi, which was associated with excessive inflammation and severe disease. Herein we examine ...
Leto: 2025 Vir: Repozitorij Univerze v Ljubljani (RUL)
Št. zadetkov: 2
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