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Št. zadetkov: 2
Exocytosis of insulin in vivo maturation of mouse endocrine pancreas
Aldo Rozzo, Tiziana Meneghel-Rozzo, Saška Lipovšek Delakorda, Shi-Bing Yang, Marjan Rupnik
Objavljeni znanstveni prispevek na konferenci
Oznake: biologija celice;sprostitev inzulina;embrio;cell biology;insulin release;embrios;newborn;beta-cell maturation;developing pancreas;
The aim of this study was to define when an insulin-positive cell becomes functional in vivo and starts to exocytose insulin in a regulated nutrient-dependent manner. Insulin-positive cells appear in embryonic life (midgestation) and complete their maturation, presumably around birth. In order to wo ...
Leto: 2009 Vir: Fakulteta za naravoslovje in matematiko (UM FNM)
pH-dependence of glucose- dependent activity of beta cell networks in acute mouse pancreatic tissue slice
Sandra Postić, Marko Gosak, Wen-Hao Tsai, Johannes Pfabe, Srdjan Sarikas, Andraž Stožer, Dean Korošak, Shi-Bing Yang, Marjan Rupnik
Izvirni znanstveni članek
Oznake: izločanje inzulina;razdražljivost membrane;kalijevi kanali;omrežje beta celic;kolektivna dejavnost;kalcijevi valovi;insulin secretion;membrane excitability;potassium channels;beta cell network;collective activity;calcium waves;pancreatic islets;pH-dependence;
Extracellular pH has the potential to affect various aspects of the pancreatic beta cell function. To explain this effect, a number of mechanisms was proposed involving both extracellular and intracellular targets and pathways. Here, we focus on reassessing the influence of extracellular pH on gluco ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Št. zadetkov: 2
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