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Biochemical and cellular studies of three human 3-phosphoglycerate dehydrogenase variants responsible for pathological reduced L-serine levels
Giulia Murtas, Elena Zerbini, Valentina Rabattoni, Zoraide Motta, Laura Caldinelli, Marco Orlando, Francesco Marchesani, Barbara Campanini, Silvia Sacchi, Loredano Pollegioni
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Oznake: L-serine;serinosome;phosphoglycerate dehydrogenase;mutants;aggregation;neurological impairment;
In the brain, the non‐essential amino acid L‐serine is produced through the phosphorylated pathway (PP) starting from the glycolytic intermediate 3‐phosphoglycerate: among the different roles played by this amino acid, it can be converted into D‐serine and glycine, the two main co‐agonists of NMDA r ...
Leto: 2024 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
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