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Št. zadetkov: 3
A virus based vaccine combined with IL12 gene therapy eradicates aggressive melanoma
Nuša Brišar, Katja Šuster, Simona Kranjc Brezar, Andrej Cör
Izvirni znanstveni članek
Oznake: immunotherapy;bacteriophages;bacteriophage display technology;bacteriophage vaccine;interleukin;gene electrotransfer;malignant melanoma;
Our study introduces a novel bacteriophage-based vaccine strategy and evaluates its antitumor efficacy, both as a standalone therapy and in combination with gene electrotransfer (GET) of interleukin-12 (IL-12) plasmids. Using phage display technology, we produced engineered M13 bacteriophages expres ...
Leto: 2025 Vir: Fakulteta za vede o zdravju (UP FVZ)
Tumor perfusion evaluation using dynamic contrast-enhanced ultrasound after electrochemotherapy and IL-12 plasmid electrotransfer in murine melanoma
Maja Brložnik, Nina Boc, Maja Čemažar, Gregor Serša, Maša Bošnjak, Simona Kranjc Brezar, Darja Pavlin
Izvirni znanstveni članek
Oznake: melanoma;therapy;electrochemotherapy;bleomycin;therapeutic use;mice;biophysics;cancer;medical research;
Electrochemotherapy with bleomycin (ECT BLM) is an effective antitumor treatment already used in clinical oncology. However, ECT alone is still considered a local antitumor therapy because it cannot induce systemic immunity. When combined with adjuvant gene electrotransfer of plasmid DNA encoding IL ...
Leto: 2021 Vir: Onkološki inštitut Ljubljana (OI)
Adjuvant TNF-a therapy to electrochemotherapy with intravenous cisplatin in murine sarcoma exerts synergistic antitumor effectiveness
Vesna Todorović, Maja Čemažar, Urška Kamenšek, Urša Lampreht Tratar, Simona Kranjc, Andrej Cör, Gregor Serša, Janez Ščančar, Monika Štimac, Maja Čemažar, Vesna Todorović, Janez Ščančar, Urša Lampreht Tratar, Monika Savarin, Urška Kamenšek, Simona Kranjc Brezar, Andrej Cör, Gregor Serša
Izvirni znanstveni članek
Oznake: electrochemotherapy;TNF;adjuvant immunotherapy;cisplatin;
Background. Electrochemotherapy is a tumour ablation modality, based on electroporation of the cell membrane, allowing non-permeant anticancer drugs to enter the cell, thus augmenting their cytotoxicity by orders of magnitude. In preclinical studies, bleomycin and cisplatin proved to be the most sui ...
Leto: 2015 Vir: Univerza v Ljubljani (UL)
Št. zadetkov: 3
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