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Št. zadetkov: 8
Selective response to omalizumab in a patient with concomitant ncMCAS and POTS
Mark Kačar, S Denman, Sinisa Savic
Kratki znanstveni prispevek
Oznake: nonclonal mast cell activation syndrome;
Selective response to omalizumab in a patient with concomitant ncMCAS and POTS : what does it teach us about the underlying disease?
Leto: 2018 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Hereditary systemic autoinflammatory diseases and Schnitzler's syndrome
Mark Kačar, Shelly Pathak, Sinisa Savic
Pregledni znanstveni članek
Oznake: autoinflammatory diseases;pyrin-associated autoinflammatory diseases;NLRP3-related autoinflammatory diseases;undifferentiated systemic autoinflammatory disease;relopathies;
The systemic autoinflammatory diseases are disorders of the innate immune system distinguished by severe inflammation resulting from dysregulation of the innate immune system. Hereditary fever syndromes, such as FMF, TNF receptor-associated periodic syndrome, cryopyrin-associated periodic syndromes ...
Leto: 2019 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
ǂThe ǂefficacy, safety and tolerability of canakinumab in the treatment of familial Mediterranean fever
Mark Kačar, Sinisa Savic, Jeroen CH van der Hilst
Pregledni znanstveni članek
Oznake: canakinumab;anti-IL1 terapija;anti-IL1 therapy;
Familial Mediterranean Fever (FMF) is the most prevalent genetic autoinflammatory disorder. In most patients, treatment with colchicine can prevent attacks of fever and inflammation. However, 5%-10% of patients are resistant to colchicine treatment, while a similar percentage cannot tolerate colchic ...
Leto: 2020 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Mixed results with baricitinib in biological-resistant adult-onset Still's disease and undifferentiated systemic autoinflammatory disease
Mark Kačar, John Fitton, Andrew K Gough, Maya H Buch, Dennis McGonagle, Sinisa Savic
Kratki znanstveni prispevek
Oznake: undifferentiated systemic autoinflammatory disease;disease-modifying antirheumatic drugs;
This clinical case series describes our experience with the use of Janus kinase 1/2 inhibitor baricitinib in two patients suffering from refractory adult-onset Still's disease (AOSD) as well as in one case suffering from AOSD-like autoinflammatory disease in the context of myelodysplastic syndrome. ...
Leto: 2020 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Identification of critical transcriptomic signaling pathways in patients with H syndrome and Rosai-Dorfman disease
Samuel Lara-Reyna, James A. Poulter, Elton J.R. Vasconcelos, Mark Kačar, Michael F. McDermott, Reuben Tooze, Rainer Doffinger, Sinisa Savic
Izvirni znanstveni članek
Oznake: sindrom H;sistemska avtovnetna bolezen;H syndrome;systemic autoinflammatory disease;
Biallelic mutations in SLC29A3 cause histiocytosis-lymphadenopathy plus syndrome, also known as H syndrome (HS). HS is a complex disorder, with ~ 25% of patients developing autoinflammatory complications consisting of unexplained fevers, persistently elevated inflammatory markers, and unusual lympha ...
Leto: 2021 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Evidence of B cell clonality and investigation into properties of the IgM in patients with Schnitzler syndrome
Shelly Pathak, Dorota Rowczenio, Samuel Lara-Reyna, Mark Kačar, Roger Owen, Gina Doody, Karoline Krause, Helen J Lachmann, Rainer Doffinger, Darren Newton, Sinisa Savic
Izvirni znanstveni članek
Oznake: autoinflammatory diseases;IgM;
The Schnitzler Syndrome (SchS) is an acquired, autoinflammatory condition successfully treated with IL-1 inhibition. The two main defining features of this late-onset condition are neutrophilic urticarial dermatoses (NUD) and the presence of an IgM monoclonal component. While the former aspect has b ...
Leto: 2020 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
ǂThe ǂuse of drug provocation testing in the investigation of suspected immediate perioperative allergic reactions
Lene Heise Garvey, D. Ebo, Mogens Krøigaard, Sinisa Savic, Russel C. Clarke, Peter J. Cooke, Pascale Dewachter, Tomaz Garcez, Anne Berit Guttormsen, Philip M. Hopkins, Peter Kopač
Pregledni znanstveni članek
Oznake: provokacijsko testiranje;provokacijski testiranje z zdravili;challenge testing;drug provocation test;
Suspected perioperative allergic reactions are often severe. To avoid potentially life-threatening re-exposure to the culprit drug, establishing a firm diagnosis and identifying the culprit is crucial. Drug provocation tests are considered the gold standard in drug allergy investigation but have not ...
Leto: 2019 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Neutralizing anti-interferon-[gamma] autoantibodies
Mark Kačar, Paulina Cortes-Acevedo, Vinesh Patel, Clive Carter, Pamela Hughes, Hugh P. McGann, Effrossyni Gkrania-Klotsas, Helen Baxendale, Gabriela Barcenas-Morales, Rainer Doffinger, Sinisa Savic
Kratki znanstveni prispevek
Oznake: sindrom akutne dihalne stiske;acute respiratory distress syndrome;
Neutralizing anti-interferon-[gamma] autoantibodies: an ameliorating factor in COVID-19 infection?
Leto: 2021 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Št. zadetkov: 8
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