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Why and How to Control P-Chirality in Phosphorothioated Therapeutic Oligonucleotides
Tanja Poredoš, Marko Trampuž, Tjaša Gornik, Klemen Naveršnik, Maša Sinreih, Samo Pirc, Zdenko Časar
Pregledni znanstveni članek
Oznake: biopolymers;genetics;molecular structure;therapeutics;
A surge in the approval of therapeutic oligonucleotides since 2016 has made this class of chemical modalities an essential toolbox for addressing unmet medical needs in the realm of rare or difficult-to-treat diseases. Therapeutic oligonucleotides are complex drugs, primarily due to the active pharm ...
Leto: 2024 Vir: Repozitorij Univerze v Ljubljani (RUL)
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