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Št. zadetkov: 4
Detection and quantification of exhaled volatile organic compounds in mechanically ventilated patients
Pouline M. van Oort, I. R. White, Waqar Ahmed, Craig Johnson, Jonathan Bannard-Smith, Timothy Felton, Lieuwe D. Bos, Royston Goodacre, Paul Dark, Stephen J Fowler
Izvirni znanstveni članek
Oznake: volatile organic compounds;infection;breath;ventilator associated pneumonia;
Exhaled breath analysis is a promising new diagnostic tool, but currently no standardised method for sampling is available in mechanically ventilated patients. We compared two breath sampling methods, first using an artificial ventilator circuit, then in “real life” in mechanically ventilated patien ...
Leto: 2021 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Untargeted molecular analysis of exhaled breath as a diagnostic test for ventilator-associated lower respiratory tract infections (BreathDx)
Pouline M. van Oort, Tamara M. E. Nijsen, I. R. White, Hugo Knobel, Timothy Felton, Nicholas J. W. Rattray, Oluwasola Lawal, Murtaza Bulut, Waqar Ahmed, Antonio Artigas
Kratki znanstveni prispevek
Oznake: ventilator-associated pneumonia;breath analysis;volatile organic compounds;metabolomics;intensive care;hospital acquired infections;
Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with ...
Leto: 2021 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Composition and diversity analysis of the lung microbiome in patients with suspected ventilator-associated pneumonia
Dominic Fenn, Mahmoud I. Abdel-Aziz, Pouline M. van Oort, Paul Brinkman, Waqar Ahmed, Timothy Felton, Antonio Artigas, Pedro Póvoa, Ignacio Martin-Loeches, I. R. White
Izvirni znanstveni članek
Oznake: microbiome;next-generation sequencing;ventilator-associated pneumonia;
Background: Ventilator-associated pneumonia (VAP) is associated with high morbidity and health care costs, yet diagnosis remains a challenge. Analysis of airway microbiota by amplicon sequencing provides a possible solution, as pneumonia is characterised by a disruption of the microbiome. However, s ...
Leto: 2022 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Pharmacokinetics/pharmacodynamics of antiviral agents used to treat SARS-CoV-2 and their potential interaction with drugs and other supportive measures
Markus Zeitlinger, Birgit C. P. Koch, Roger Bruggemann, Pieter De Cock, Timothy Felton, Maya Hites, Jennifer Le, Sonia Luque, Alasdair P. MacGowan, Deborah J. E. Marriott, Kristina Nadrah
Pregledni znanstveni članek
Oznake: SARS-CoV-2;COVID-19;pharmacokinetics;major supportive therapies;
There is an urgent need to identify optimal antiviral therapies for COVID-19 caused by SARS-CoV-2. We have conducted a rapid and comprehensive review of relevant pharmacological evidence, focusing on (1) the pharmacokinetics (PK) of potential antiviral therapies; (2) coronavirus-specific pharmacodyn ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 4
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