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Št. zadetkov: 6
Zaščitni in škodljivi učinki aripiprazola in olanzapina v celičnih modelih jeter
Tinkara Pirc Marolt, Irina Milisav
Doktorska disertacija
Oznake: aripiprazol;olanzapin;jetrne celice;viabilnost;citotoksičnost;apoptoza;proteasomska aktivnost;avtofagija;metabolizem mitohondrijev;antioksidativni odziv;oksidativni stres;
Aripiprazol (ARI) in olanzapin (OLA) sta pogosto uporabljena atipična antipsihotika s številnimi prednostmi pri zdravljenju shizofrenije in bipolarne motnje. Oba antipsihotika izkazujeta zaščitno delovanje, vendar so ob dolgotrajni terapiji zlasti problematične metabolne komplikacije, katerih vzroki ...
Leto: 2023 Vir: Medicinska fakulteta (UL MF)
Medical and dietary uses of N-acetylcysteine
Špela Šalamon, Barbara Kramar, Tinkara Pirc Marolt, Borut Poljšak, Irina Milisav
Pregledni znanstveni članek
Oznake: N-acetylcysteine;acetylcysteine;pharmacology;physiology;dietary supplements;aging;sports;
N-acetylcysteine (NAC), a plant antioxidant naturally found in onion, is a precursor to glutathione. It has been used as a drug since the 1960s and is listed on the World Health Organization (WHO) Model List of Essential Medicines as an antidote in poisonings. There are numerous other uses or propos ...
Leto: 2019 Vir: Digitalna knjižnica Univerze v Mariboru (DKUM)
Aripiprazole reduces liver cell division
Tinkara Pirc Marolt, Barbara Kramar, Klara Bulc Rozman, Dušan Šuput, Irina Milisav
Ni določena
Oznake: Aripiprazole;Olanzapine;chemical and drug induced liver injury;antipsychotics;second-generation antipsychotics;
Effects of aripiprazole on dopamine regulation are being tested as a treatment for patients with a dual diagnosis of schizophrenia and addictions, often cocaine dependence. Aripiprazole has one of the fewest side-effects among the second-generation antipsychotics. Nevertheless, severe aripiprazole h ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Znotrajcelična okužba z bakterijo Rhabdochlamydia porcellionis v tkivih raka Porcellio scaber
Tinkara Pirc Marolt, Rok Kostanjšek, Rok Kostanjšek, Nada Žnidaršič, Nada Žnidaršič, Damjana Drobne
Magistrsko delo
Oznake: znotrajcelična okužba;širjenje okužbe;melanizacija;nodulacija;
Znotrajcelična okužba z bakterijo Rhabdochlamydia porcellionis v tkivih raka Porcellio scaber
Leto: 2014 Vir: Biotehniška fakulteta (UL BF)
Therapeutic dosage of antipsychotic drug aripiprazole induces persistent mitochondrial hyperpolarisation, moderate oxidative stress in liver cells, and haemolysis
Tinkara Pirc Marolt, Barbara Kramar, Andrej Vovk, Helena Podgornik, Dušan Šuput, Irina Milisav
Ni določena
Oznake: mitochondria;hyperpolarization;aripiprazole;cell respiration;schizophrenia;olanzapine;hepatocytes;drug-induced liver injury;
Aripiprazole has fewer metabolic side effects than other antipsychotics; however, there are some severe ones in the liver, leading to drug-induced liver injury. Repeated treatment with aripiprazole affects cell division. Since this process requires a lot of energy, we decided to investigate the impa ...
Leto: 2023 Vir: Medicinska fakulteta (UL MF)
High burden of clonal mast cell disorders and hereditary α-[alpha]tryptasemia in patients who need Hymenoptera venom immunotherapy
Peter Korošec, Gunter J. Sturm, Jonathan J. Lyons, Tinkara Pirc Marolt, Manca Svetina, Mitja Košnik, Matija Rijavec, Urban Čerpes, Grzegorz Porebski, Branko Pevec, Eva Schadelbauer, Peter Kopač, Julij Šelb, Matevž Škerget, Ewa Czarnobilska, Wojciech Dyga, Sanja Popović-Grle, Miroslav Samaržija, Lisa Arzt-Gradwohl, Mihaela Zidarn, Mark Kačar, Nina Frelih, Nika Lalek, Ajda Demšar Luzar, Samo Zver
Izvirni znanstveni članek
Oznake: anaphylaxis;hereditary α-tryptasemia;hypersensitivity;immunotherapy;mast cell;mastocytosis;venom;
Background In patients who require venom immunotherapy (VIT), there is a need to identify underlying mast cell (MC) disorders since these may affect the risk and severity of future sting reactions and the long-term effectiveness of VIT. Methods 1319 individuals with Hymenoptera venom allergy (H ...
Leto: 2024 Vir: Repozitorij Univerze v Ljubljani (RUL)
Št. zadetkov: 6
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