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In the body, all cell surfaces are covered with glycans, and many regulatory components have carbohydrates attached to them, which can aid in their function. Galectins are a family of proteins which can bind to specific glycans and oligosaccharides and cross-link them to influence a wide range of ce ...

Galectins are among organisms' most abundantly expressed lectins (carbohydrate-binding proteins) that specifically bind β-galactosides. They act not only outside the cell, where they bind to extracellular matrix glycans, but also inside the cell, where they have a significant impact on signaling pat ...

Galectins are galactoside-binding proteins that play a role in various pathophysiological conditions, making them attractive targets in drug discovery. We have designed and synthesised a focused library of aromatic 3-triazolyl-1-thiogalactosides targeting their core site for binding of galactose and ...