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Endoglin (CD105) silencing mediated by shRNA under the control of Endothelin-1 promoter for targeted gene therapy of Melanoma
Nataša Tešić, Urška Kamenšek, Gregor Serša, Simona Kranjc, Monika Štimac, Urša Lampreht Tratar, Véronique Préat, Gaëlle Vandermeulen, Miha Butinar, Boris Turk, Maja Čemažar
Izvirni znanstveni članek
Oznake: melanoma;electroporation;endoglin (CD105);endothelin-1;gene therapy;
Endoglin (CD105), a transforming growth factor (TGF)-% coreceptor, and endothelin-1, a vasoconstrictor peptide, are both overexpressed in tumor endothelial and melanoma cells. Their targeting is therefore a promising therapeutic approach for melanoma tumors. The aim of our study was to construct a e ...
Leto: 2015 Vir: Fakulteta za vede o zdravju (UP FVZ)
Št. zadetkov: 1
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