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Overcoming drug impurity challenges in amorphous solid dispersion with rational development of biorelevant dissolution-permeation method
Tilen Huzjak, Ognen Jakasanovski, Katja Berginc, Vid Puž, Katarina Zajc-Kreft, Žiga Jeraj, Biljana Janković
Izvirni znanstveni članek
Oznake: biorelevant dissolution-permeation;hot-melt extrusion;In vitro – in vivo correlation;liquid-liquid phase separation;solid dispersion;supersaturation;
Hot-melt extrusion is often used to prepare amorphous solid dispersion to overcome low drug solubility and enhance bio-performance of the formulation. Due to the uniqueness of each drug - polymer combination and its physico-chemical properties, setting the appropriate HME barrel temperature, feed ra ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
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