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Št. zadetkov: 8
Spremembe znotrajcelične koncentracije kalcijevih ionov v akutnih tkivnih rezinah trebušne slinavke glodavskih modelov
Viljem Pohorec, Andraž Stožer, Jurij Dolenšek
Doktorska disertacija
Oznake: celice beta;mišji model;slikanje kalcija;glukozna odvisnost;tkivna rezina;
Sladkorna bolezen tipa 2 globalno predstavlja vse večji javnozdravstveni problem, številne raziskave pa se posledično osredotočajo na mehanizme normalnega in motenega delovanja Langerhansovih otočkov trebušne slinavke. Laboratorijske miši zaradi strukturnih in funkcionalnih podobnosti Langerhansovih ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Segmentacija slik celic z algoritmi globokega učenja
Gregor Gorjanc, Sašo Karakatič, Viljem Pohorec
Magistrsko delo
Oznake: segmentacija slik;nenadzorovano učenje;W-Net;nevronske mreže;celice beta;magistrske naloge;
V magistrskem delu smo se spoznali s problematiko sladkorne bolezni, ki se odraža z nepravilnim obnašanjem celic beta v trebušni slinavki. Seznanili smo se s postopkom označevanja slik Langerhansovih otočkov, ki vsebujejo celice beta. S ciljem avtomatizacije procesa ročnega označevanja slik smo se o ...
Leto: 2022 Vir: Fakulteta za elektrotehniko, računalništvo in informatiko (UM FERI)
Alpha cell stimulus-secretion coupling and intercellular interactions in health and type 2 diabetes
Viljem Pohorec, Nika Zadravec, Marko Turk, Jurij Dolenšek, Andraž Stožer
Pregledni znanstveni članek
Oznake: Alpha cell;calcium imaging;epinephrine;physiology;type 2 diabetes mellitus;
Leto: 2023 Vir: Medicinska fakulteta (UM MF)
Ultrafast multicellular calcium imaging of calcium spikes in mouse beta cells in tissue slices
Jurij Dolenšek, Viljem Pohorec, Maša Skelin, Marko Gosak, Andraž Stožer
Izvirni znanstveni članek
Oznake: beta cell;calcium imaging;calcium oscillations;calcium spikes;physiology;
Background: The crucial steps in beta cell stimulus-secretion coupling upon stimulation with glucose are oscillatory changes in metabolism, membrane potential, intracellular calcium concentration, and exocytosis. The changes in membrane potential consist of bursts of spikes, with silent phases betwe ...
Leto: 2025 Vir: Medicinska fakulteta (UM MF)
Glucose-stimulated calcium dynamics in beta cells from male C57BL/6J, C57BL/6N, and NMRI mice: a comparison of activation, activity, and deactivation properties in tissue slices
Viljem Pohorec, Lidija Križančić Bombek, Maša Skelin, Jurij Dolenšek, Andraž Stožer
Izvirni znanstveni članek
Oznake: beta cell;mouse models;calcium imaging;glucose-dependence;tissue slice;
Although mice are a very instrumental model in islet beta cell research, possible phenotypic differences between strains and substrains are largely neglected in the scientific community. In this study, we show important phenotypic differences in beta cell responses to glucose between C57BL/6J, C57BL ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Glucose-dependent activation, activity, and deactivation of beta cell networks in acute mouse pancreas tissue slices
Andraž Stožer, Maša Skelin, Marko Gosak, Lidija Križančić Bombek, Viljem Pohorec, Marjan Rupnik, Jurij Dolenšek
Izvirni znanstveni članek
Oznake: beta cells;calcium imaging;glucose-dependence;network analysis;
Many details of glucose-stimulated intracellular calcium changes in [beta] cells during activation, activity, and deactivation, as well as their concentration-dependence, remain to be analyzed. Classical physiological experiments indicated that in islets, functional differences between individual ce ...
Leto: 2021 Vir: Medicinska fakulteta (UM MF)
ǂThe ǂrole of cAMP in beta cell stimulus-secretion and intercellular coupling
Andraž Stožer, Eva Paradiž, Viljem Pohorec, Jurij Dolenšek, Lidija Križančić Bombek, Marko Gosak, Maša Skelin
Pregledni znanstveni članek
Oznake: cAMP;beta cells;stimulus-secretion coupling;intercellular coupling;PKA;Epac2A;
Pancreatic beta cells secrete insulin in response to stimulation with glucose and other nutrients, and impaired insulin secretion plays a central role in development of diabetes mellitus. Pharmacological management of diabetes includes various antidiabetic drugs, including incretins. The incretin ho ...
Leto: 2021 Vir: Medicinska fakulteta (UM MF)
Network representation of multicellular activity in pancreatic islets
Marko Šterk, Yaowen Zhang, Viljem Pohorec, Eva Paradiž, Jurij Dolenšek, Richard K. P. Benninger, Andraž Stožer, Vira Kravets, Marko Gosak
Izvirni znanstveni članek
Oznake: Langerhansovi otočki;celice beta;kalcijeva signalizacija;medcelična komunikacija;funkcionalna omrežja;islets of Langerhans;beta cells;calcium signaling;intercellular communication;functional networks;myosin model;
Within the islets of Langerhans, beta cells orchestrate synchronized insulin secretion, a pivotal aspect of metabolic homeostasis. Despite the inherent heterogeneity and multimodal activity of individual cells, intercellular coupling acts as a homogenizing force, enabling coordinated responses throu ...
Leto: 2024 Vir: Medicinska fakulteta (UM MF)
Št. zadetkov: 8
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