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Rapid UPLC-ESI-MS/MS based assay for discovery of UDP-N-acetylmuramoyl-L-alanine:D-glutamate (MurD) ligase inhibitors
Vjekoslava Car, Samo Andrenšek
Magistrsko delo
Oznake: Mur ligases;inhibitors;liquid chromatography;tandem mass spectrometry;antibiotics;drug discovery;master's thesis;
A rapid, selective, robust and sensitive analytical assay method, operating in a short time frame with acceptable levels of precision, linear range and the accuracy necessary for successful Mur ligases inhibitors discovery, was developed. An LC-MS/MS analytical procedure was designed for the determ ...
Leto: 2016 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
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