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Št. zadetkov: 3
Structural polymorphism driven by a register shift in a CGAG-rich region found in the promoter of the neurodevelopmental regulator AUTS2 gene
Aleš Novotný, Janez Plavec, Vojč Kocman
Izvirni znanstveni članek
Oznake: biokemija;razvoj možganov;nevroni;proteini;AUTS2;
The AUTS2 gene has been shown to influence brain development by controlling the number of neurons, promoting the growth of axons and dendrites and regulating neuronal migration. The expression of two isoforms of AUTS2 protein is precisely regulated and misregulation of their expression has been corr ...
Leto: 2023 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
High-resolution structure of RNA G-quadruplex containing unique structural motifs originating from the 5′-UTR of human tyrosine kinase 2 (TYK2)
Maria Toplishek, Janez Plavec, Vojč Kocman
Izvirni znanstveni članek
Oznake: biokemija;g-kvadrupleksi;spektroskopija;NMR;vnetja;bolezni;COVID-19;
Tyrosine kinase 2 (TYK2) is a member of the JAK family of nonreceptor-associated tyrosine kinases together with highly homologous JAK1, JAK2, and JAK3 paralogues. Overexpression of TYK2 is associated with several inflammatory diseases, including severe complications during the COVID-19 infection. Si ...
Leto: 2024 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Protein G-quadruplex interactions and their effects on phase transitions and protein aggregation
Bikash Ranjan Sahoo, Vojč Kocman, Nathan Clark, Nikhil Myers, Xiexiong Deng, Ee L. Wong, Harry J. Yang, Anita Kotar, Bryan B. Guzman, Daniel Dominguez, Janez Plavec, James C. A. Bardwell
Izvirni znanstveni članek
Oznake: biokemija;g-kvadrupleksi;proteini;beljakovine;mRNK;geni;
Leto: 2024 Vir: Kemijski inštitut (KI)
Št. zadetkov: 3
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