Št. zadetkov: 10
Pregledni znanstveni članek
Oznake:
breath analysis;disease diagnosis;exhaled volatile organic compounds;respiratory disease;environmental exposure analysis;
The theoretical basis of eVOCs as biomarkers for respiratory disease diagnosis is described, followed by a review of the potential biomarkers that have been proposed as targets from in vitro studies. The utility of these targets is then discussed based on comparison with results from clinical breath ...
Leto:
2024
Vir:
Repozitorij Univerze v Novi Gorici (RUNG)
Izvirni znanstveni članek
Oznake:
bacteria;exhaled breath;infection;ventilator-associated pneumonia;volatile organic compounds;
Ventilator-associated pneumonia (VAP) is a healthcare-acquired infection arising from the invasion of the lower respiratory tract by opportunistic pathogens in ventilated patients. The current method of diagnosis requires the culture of an airway sample such as bronchoalveolar lavage, which is invas ...
Leto:
2018
Vir:
Repozitorij Univerze v Novi Gorici (RUNG)
Izvirni znanstveni članek
Oznake:
asthma;exhaled volatile organic compounds;pulmonology;breath metabolomics;
Background Inhaled mannitol provokes bronchoconstriction via mediators released during osmotic degranulation of inflammatory cells, and, hence represents a useful diagnostic test for asthma and model for acute attacks. We hypothesised that the mannitol challenge would trigger changes in exhaled vola ...
Leto:
2023
Vir:
Repozitorij Univerze v Novi Gorici (RUNG)
Izvirni znanstveni članek
Oznake:
stroke;metabolomics;breath;VOCs;inflammation;
Inflammation is strongly implicated in both injury and repair processes occurring after stroke. In this exploratory study we assessed the feasibility of repeated sampling of exhaled volatile organic compounds and performed an untargeted metabolomic analysis of plasma collected at multiple time perio ...
Leto:
2021
Vir:
Repozitorij Univerze v Novi Gorici (RUNG)
Izvirni znanstveni članek
Oznake:
volatile organic compounds;fungi;mycelial growth;
Pulmonary aspergillosis can cause serious complications in people with a suppressed immune system. Volatile metabolites emitted by Aspergillus spp. have shown promise for early detection of pathogenicity. However, volatile profiles require further research, as effective headspace analysis methods ar ...
Leto:
2018
Vir:
Repozitorij Univerze v Novi Gorici (RUNG)
Izvirni znanstveni članek
Oznake:
breath volatile;VOCs;infection;VAP;respiratory pathogens;
Background
Early and accurate recognition of respiratory pathogens is crucial to prevent increased risk of mortality in critically ill patients. Microbial-derived volatile organic compounds (mVOCs) in exhaled breath could be used as non-invasive biomarkers of infection to support clinical diagnosis ...
Leto:
2023
Vir:
Repozitorij Univerze v Novi Gorici (RUNG)
Izvirni znanstveni članek
Oznake:
volatile organic compounds;infection;breath;ventilator associated pneumonia;
Exhaled breath analysis is a promising new diagnostic tool, but currently no standardised method for sampling is available in mechanically ventilated patients. We compared two breath sampling methods, first using an artificial ventilator circuit, then in “real life” in mechanically ventilated patien ...
Leto:
2021
Vir:
Repozitorij Univerze v Novi Gorici (RUNG)
Izvirni znanstveni članek
Oznake:
breath;diagnosis;ventilator-associated pneumonia;
Ventilator-associated pneumonia commonly occurs in critically ill patients. Clinical suspicion results in overuse of antibiotics, which in turn promotes antimicrobial resistance. Detection of volatile organic compounds in the exhaled breath of critically ill patients might allow earlier detection of ...
Leto:
2023
Vir:
Repozitorij Univerze v Novi Gorici (RUNG)
Kratki znanstveni prispevek
Oznake:
ventilator-associated pneumonia;breath analysis;volatile organic compounds;metabolomics;intensive care;hospital acquired infections;
Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with ...
Leto:
2021
Vir:
Repozitorij Univerze v Novi Gorici (RUNG)
Izvirni znanstveni članek
Oznake:
microbiome;next-generation sequencing;ventilator-associated pneumonia;
Background: Ventilator-associated pneumonia (VAP) is associated with high morbidity and health care costs, yet diagnosis remains a challenge. Analysis of airway microbiota by amplicon sequencing provides a possible solution, as pneumonia is characterised by a disruption of the microbiome. However, s ...
Leto:
2022
Vir:
Repozitorij Univerze v Novi Gorici (RUNG)