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Št. zadetkov: 2
Allosteric coupling between transmembrane segment 4 and the selectivity filter of TALK1 potassium channels regulates their gating by extracellular pH
Wen-Hao Tsai, Cédric Grauffel, Yueh-Ming Huang, Sandra Postić, Marjan Rupnik, Carmay Lim, Shi-Bing Yang
Izvirni znanstveni članek
Oznake: potassium channel;molecular dynamics;molecular modeling;structural model;K2P;TALK1;pH sensing;C-type gate;channel activation;
Opening of two-pore domain K+ channels (K2Ps) is regulated by various external cues, such as pH, membrane tension, or temperature, which allosterically modulate the selectivity filter (SF) gate. However, how these cues cause conformational changes in the SF of some K2P channels remains unclear. Here ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
pH-dependence of glucose- dependent activity of beta cell networks in acute mouse pancreatic tissue slice
Sandra Postić, Marko Gosak, Wen-Hao Tsai, Johannes Pfabe, Srdjan Sarikas, Andraž Stožer, Dean Korošak, Shi-Bing Yang, Marjan Rupnik
Izvirni znanstveni članek
Oznake: izločanje inzulina;razdražljivost membrane;kalijevi kanali;omrežje beta celic;kolektivna dejavnost;kalcijevi valovi;insulin secretion;membrane excitability;potassium channels;beta cell network;collective activity;calcium waves;pancreatic islets;pH-dependence;
Extracellular pH has the potential to affect various aspects of the pancreatic beta cell function. To explain this effect, a number of mechanisms was proposed involving both extracellular and intracellular targets and pathways. Here, we focus on reassessing the influence of extracellular pH on gluco ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Št. zadetkov: 2
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