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Št. zadetkov: 3
From tryptophan-based amides to tertiary amines
Anže Meden, Damijan Knez, Xavier Brazzolotto, Florian Nachon, Jose Dias, Jurij Svete, Jure Stojan, Uroš Grošelj, Stanislav Gobec
Izvirni znanstveni članek
Oznake: zaviralci holinesteraze;butirilholinesteraza;karbamat;psevdoireverzibilna inhibicija;cholinesterase inhibitors;Alzheimer's disease;butyrylcholinesterase;carbamate;pseudoirreversible inhibition;
Lead optimization of a series of tryptophan-based nanomolar butyrylcholinesterase (BChE) inhibitors led to tertiary amines as highly potent, achiral, sp (Chierrito et al., 2018) [3]-rich analogues with better synthetic accessibility and high selectivity over acetylcholinesterase (one to ten thousand ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
N-propargylpyrrolidine-based butyrylcholinesterase and monoamine oxidase inhibitors
Urban Košak, Damijan Knez, Anja Pišlar, Selena Horvat, Simon Žakelj, Alexandre Igert, Jose Dias, Florian Nachon, Xavier Brazzolotto, Stanislav Gobec
Izvirni znanstveni članek
Oznake: butyrylcholinesterase;acetylcholinesterase;monoamine oxidase;monoamine oxidase A;monoamine oxidase B;enzyme inhibitors;pyrrolidines;
Butyrylcholinesterase (BChE) inhibitors are or could be used for the treatment of Alzheimer's disease, canine cognitive dysfunction, depression, multiple sclerosis, heroin abuse and metabolic disorders. Monoamine oxidase (MAO) inhibitors are or could be used for the treatment of depression, anxiety, ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes
Stane Pajk, Damijan Knez, Urban Košak, Maja Zorović, Xavier Brazzolotto, Nicolas Coquelle, Florian Nachon, Jacques-Philippe Colletier, Marko Živin, Jure Stojan, Stanislav Gobec
Izvirni znanstveni članek
Oznake: butyrylcholinesterase;inhibitor;probe;fluorescence;
Brain butyrylcholinesterase (BChE) is an attractive target for drugs designed for the treatment of Alzheimer's disease (AD) in its advanced stages. It also potentially represents a biomarker for progression of this disease. Based on the crystal structure of previously described highly potent, revers ...
Leto: 2020 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 3
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