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Št. zadetkov: 5
Kratki znanstveni prispevek
Oznake: COX2;PGE2;human;cancer;myeloid-derived suppressor cells;immune dysfunction;immunotherapy;transplantation;
PGE(2) is the key factor needed for MDSCs development, accumulation and functional stability. PGE(2) initiates an EP2/EP4-mediated positive feedback between COX2 and PGE(2) in monocytic precursors, redirecting dendritic cell differentiation to MDSCs. COX2- or EP2/EP4- blockade abrogates MDSC functio ...
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: cancer;COX2;dentritic cells;immune dysfunction;human;imunotherapy;myeloid-derived suppressor cells;PGe2;transplantation;
Myeloid-derived suppressor cells (MDSCs) are natural immunosuppressive cells and endogenous inhibitors of the immune system. We describe a simple and clinically compatible method of generating large numbers of MDSCs using the cultures of peripheral blood-isolated monocytes supplemented with prostagl ...
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: dendritske celice;prostaglandin E2;rak jajčnikov;COX2;
Dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) show opposing roles in the immune system. We report that the establishment of positive feedback loop between prostaglandin E2 (PGE2) and COX2, the key regulator of PGE2 synthesis, represents the determining factor in redirecting the ...
Leto: 2011 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: PGE-2;CXCL12;rak jajčnikov;COX2 inhibicija;
Signals mediated by CXCL12 (SDF1) and its receptor CXCR4 are centrally involved in cancer progression, both directly by activating cancer cells and indirectly by inducing angiogenesis plus recruiting T regulatory and plasmacytoid dendritic immune cells. Here we show that in ascites isolated from ova ...
Leto: 2011 Vir: Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake: imunska regulacija;T-celice;imunska odzivnost;dendritične celice;
The generation of effective type 1 T helper (Th1) cell responses is required for immunity against intracellular bacteria. However, some intracellular bacteria require interleukin (IL)-17 to drive Th1-cell immunity and subsequent protective host immunity. Here, in a model of Mycobacterium bovis Bacil ...
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 5
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