Important and specific role for basophils in acute allergic reactions

Peter Korošec (Author), Bernhard F. Gibbs (Author), Matija Rijavec (Author), Adnan Custovic (Author), Paul J. Turner (Author)

Abstract

IgE-mediated allergic reactions involve the activation of effector cells, predominantly through the high-affinity IgE receptor (FceRI) on mast cells and basophils. Although the mast cell is considered the major effector cell during acute allergic reactions, more recent studies indicate a potentially important and specific role for basophils and their migration which occurs rapidly upon allergen challenge in humans undergoing anaphylaxis. We review the evidence for a role of basophils in contributing to clinical symptoms of anaphylaxis, and discuss the possibility that basophil trafficking during anaphylaxis might be a pathogenic (to target organs) or protective (preventing degranulation in circulation) response. Finally, we examine the potential role of basophils in asthma exacerbations. Understanding the factors that regulate basophil trafficking and activation might lead to new diagnostic and therapeutic strategies in anaphylaxis and asthma.

Keywords

allergy and immunology;basophils;anaphylaxis;

Data

Language:	English
Year of publishing:	2018
Typology:	1.02 - Review Article
Publisher:	John Wiley & Sons
UDC:	616-097
COBISS:	2048254577
ISSN:	1365-2222
Views:	788
Downloads:	488
Average score:	0 (0 votes)
Metadata:

Other data

Secondary keywords:	Allergy and immunology;Basophils;Anaphylaxis;Alergija in imunologija;Bazofilci;Anafilaksija;
Source comment:	Soavtorji: Bernhard F. Gibbs, Matija Rijavec, Adnan Custovic and Paul J. Turner; Nasl. z nasl. zaslona; Opis vira z dne 7. 3. 2018;
Pages:	str. 502-512
Volume:	ǂVol. ǂ48
Issue:	ǂiss. ǂ5
Chronology:	May 2018
DOI:	10.1111/cea.13117
ID:	12255939