current status
Lene Heise Garvey (Avtor), D. Ebo (Avtor), Mogens Krøigaard (Avtor), Sinisa Savic (Avtor), Russel C. Clarke (Avtor), Peter J. Cooke (Avtor), Pascale Dewachter (Avtor), Tomaz Garcez (Avtor), Anne Berit Guttormsen (Avtor), Philip M. Hopkins (Avtor), Peter Kopač (Avtor)

Povzetek

Suspected perioperative allergic reactions are often severe. To avoid potentially life-threatening re-exposure to the culprit drug, establishing a firm diagnosis and identifying the culprit is crucial. Drug provocation tests are considered the gold standard in drug allergy investigation but have not been recommended in the investigation of perioperative allergy, mainly because of the pharmacological effects of drugs such as induction agents and neuromuscular blocking agents. Some specialised centres have reported benefits of provocation testing in perioperative allergy investigation, but the literature on the subject is limited. Here we provide a status update on the use of drug provocation testing in perioperative allergy, including its use in specific drug groups. This review is based on a literature search and experiences of the authors comprising anaesthesiologists and allergists with experience in perioperative allergy investigation. In addition, 19 participating centres in the International Suspected Perioperative Allergic Reaction Group were surveyed on the use of provocation testing in perioperative allergy investigation. A response was received from 13 centres in eight European countries, New Zealand, and the USA. Also, 21 centres from the Australian and New Zealand Anaesthetic Allergy Group were surveyed. Two centres performed provocation routinely and seven centres performed no provocations at all. Nearly half of the centres reported performing provocations with induction agents and neuromuscular blocking agents. Drug provocation testing is being used in perioperative allergy investigation in specialised centres, but collaborations between relevant specialties and multicentre studies are necessary to determine indications and establish common testing protocols.

Ključne besede

provokacijsko testiranje;provokacijski testiranje z zdravili;challenge testing;drug provocation test;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Založnik: Elsevier
UDK: 616-097
COBISS: 2048510321 Povezava se bo odprla v novem oknu
ISSN: 1471-6771
Matična publikacija: British journal of anaesthesia
Št. ogledov: 826
Št. prenosov: 338
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarne ključne besede: Allergy and immunology;Drug hypersensitivity;Anesthesia;Drug-related side effects and adverse reactions;Anaphylaxis;Perioperative period;Alergija in imunologija;Preobčutljivost za zdravila;Anestezija;Stranski in škodljivi učinki zdravil;Anafilaksija;Perioperativno obdobje;
Komentar vira: Soavtor iz Slovenije: Peter Kopac; Nasl. z nasl. zaslona; Opis vira z dne 5. 6. 2019;
Strani: str. e126-e134
Letnik: ǂVol. ǂ123
Zvezek: ǂiss. ǂ1
Čas izdaje: Jul. 2019
DOI: 10.1016/j.bja.2019.03.018
ID: 12066576